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The effect of isometric exercise of the hand on the synovial blood flow in patients with rheumatoid arthritis measured by color Doppler ultrasound

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@article{45669b47dfe546f6b7094e1ea223ce13,
title = "The effect of isometric exercise of the hand on the synovial blood flow in patients with rheumatoid arthritis measured by color Doppler ultrasound",
abstract = "In 90% of patients with rheumatoid arthritis (RA), the joints of the hand are affected. Studies of grip strength training have not indicated a negative effect on disease activity after training. Introduction of ultrasound Doppler (USD) to measure increased blood flow induced by inflammation has made it possible to investigate the direct effect on blood supply in the synovium after training. In this case-control study, 24 patients with RA with USD activity in the wrist joint participated. The USD activity was measured by the color fraction (CF) (CF = colored pixels/total number of pixels in ROI). Twenty-four patients were assigned to an 8-week grip strength training program. At baseline and after 8 weeks of training, an USD examination of the wrist joint was performed. In the training group, we measured grip strength and pain in the wrist joint. Six patients withdrew from the training because of pain or change in medication. Eighteen patients served as control group. There was a modest, not significant, decrease in the CF in response to training (1.86%; P = 0.08). Grip strength increased 8.8% after training (P = 0.055). Pain in motion deceased after training (P = 0.04). No difference in the CF was seen between the training and control groups, neither at baseline nor at follow-up (P = 0.82 and P = 0.48). Patients withdrawing from training had a significantly higher CF than the other patients (P > 0.001). The results in this study might indicate that the flow in the synovium assessed by USD is not affected by grip strength training.",
keywords = "Adult, Aged, Arthritis, Rheumatoid, Blood Flow Velocity, Case-Control Studies, Exercise, Exercise Therapy, Female, Hand Strength, Humans, Middle Aged, Outpatients, Synovial Membrane, Treatment Outcome, Ultrasonography, Doppler, Color, Wrist Joint",
author = "Karen Ellegaard and S{\o}ren Torp-Pedersen and Hans Lund and Kirsten Pedersen and Marius Henriksen and Bente Danneskiold-Sams{\o}e and Henning Bliddal",
year = "2013",
month = jan,
doi = "10.1007/s00296-011-2314-z",
language = "English",
volume = "33",
pages = "65--70",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - The effect of isometric exercise of the hand on the synovial blood flow in patients with rheumatoid arthritis measured by color Doppler ultrasound

AU - Ellegaard, Karen

AU - Torp-Pedersen, Søren

AU - Lund, Hans

AU - Pedersen, Kirsten

AU - Henriksen, Marius

AU - Danneskiold-Samsøe, Bente

AU - Bliddal, Henning

PY - 2013/1

Y1 - 2013/1

N2 - In 90% of patients with rheumatoid arthritis (RA), the joints of the hand are affected. Studies of grip strength training have not indicated a negative effect on disease activity after training. Introduction of ultrasound Doppler (USD) to measure increased blood flow induced by inflammation has made it possible to investigate the direct effect on blood supply in the synovium after training. In this case-control study, 24 patients with RA with USD activity in the wrist joint participated. The USD activity was measured by the color fraction (CF) (CF = colored pixels/total number of pixels in ROI). Twenty-four patients were assigned to an 8-week grip strength training program. At baseline and after 8 weeks of training, an USD examination of the wrist joint was performed. In the training group, we measured grip strength and pain in the wrist joint. Six patients withdrew from the training because of pain or change in medication. Eighteen patients served as control group. There was a modest, not significant, decrease in the CF in response to training (1.86%; P = 0.08). Grip strength increased 8.8% after training (P = 0.055). Pain in motion deceased after training (P = 0.04). No difference in the CF was seen between the training and control groups, neither at baseline nor at follow-up (P = 0.82 and P = 0.48). Patients withdrawing from training had a significantly higher CF than the other patients (P > 0.001). The results in this study might indicate that the flow in the synovium assessed by USD is not affected by grip strength training.

AB - In 90% of patients with rheumatoid arthritis (RA), the joints of the hand are affected. Studies of grip strength training have not indicated a negative effect on disease activity after training. Introduction of ultrasound Doppler (USD) to measure increased blood flow induced by inflammation has made it possible to investigate the direct effect on blood supply in the synovium after training. In this case-control study, 24 patients with RA with USD activity in the wrist joint participated. The USD activity was measured by the color fraction (CF) (CF = colored pixels/total number of pixels in ROI). Twenty-four patients were assigned to an 8-week grip strength training program. At baseline and after 8 weeks of training, an USD examination of the wrist joint was performed. In the training group, we measured grip strength and pain in the wrist joint. Six patients withdrew from the training because of pain or change in medication. Eighteen patients served as control group. There was a modest, not significant, decrease in the CF in response to training (1.86%; P = 0.08). Grip strength increased 8.8% after training (P = 0.055). Pain in motion deceased after training (P = 0.04). No difference in the CF was seen between the training and control groups, neither at baseline nor at follow-up (P = 0.82 and P = 0.48). Patients withdrawing from training had a significantly higher CF than the other patients (P > 0.001). The results in this study might indicate that the flow in the synovium assessed by USD is not affected by grip strength training.

KW - Adult

KW - Aged

KW - Arthritis, Rheumatoid

KW - Blood Flow Velocity

KW - Case-Control Studies

KW - Exercise

KW - Exercise Therapy

KW - Female

KW - Hand Strength

KW - Humans

KW - Middle Aged

KW - Outpatients

KW - Synovial Membrane

KW - Treatment Outcome

KW - Ultrasonography, Doppler, Color

KW - Wrist Joint

U2 - 10.1007/s00296-011-2314-z

DO - 10.1007/s00296-011-2314-z

M3 - Journal article

C2 - 22218637

VL - 33

SP - 65

EP - 70

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 1

ER -

ID: 40460750