The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

Flemming W Bach; Troels S Jensen; Jens Kastrup; Bent Stigsby; Anders Dejgård

doi:10.1016/0304-3959(90)91047-M

The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

Flemming W Bach, Troels S Jensen, Jens Kastrup, Bent Stigsby, Anders Dejgård

185 Citations (Scopus)

Abstract

In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.

Original language	English
Journal	Pain
Volume	40
Issue number	1
Pages (from-to)	29-34
Number of pages	6
ISSN	0304-3959
DOIs	https://doi.org/10.1016/0304-3959(90)91047-M
Publication status	Published - Jan 1990
Externally published	Yes

Keywords

Adult
Diabetic Neuropathies/complications
Double-Blind Method
H-Reflex/drug effects
Humans
Injections, Intravenous
Lidocaine/administration & dosage
Male
Nociceptors/drug effects
Pain/drug therapy
Reflex, Monosynaptic/drug effects
Sensory Thresholds/drug effects

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10.1016/0304-3959(90)91047-M

Cite this

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title = "The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy",

abstract = "In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.",

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year = "1990",

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doi = "10.1016/0304-3959(90)91047-M",

language = "English",

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T1 - The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

AU - Bach, Flemming W

AU - Jensen, Troels S

AU - Kastrup, Jens

AU - Stigsby, Bent

AU - Dejgård, Anders

PY - 1990/1

Y1 - 1990/1

N2 - In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.

AB - In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.

KW - Adult

KW - Diabetic Neuropathies/complications

KW - Double-Blind Method

KW - H-Reflex/drug effects

KW - Humans

KW - Injections, Intravenous

KW - Lidocaine/administration & dosage

KW - Male

KW - Nociceptors/drug effects

KW - Pain/drug therapy

KW - Reflex, Monosynaptic/drug effects

KW - Sensory Thresholds/drug effects

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DO - 10.1016/0304-3959(90)91047-M

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JO - Pain

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The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

Abstract

Keywords

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