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The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue

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  2. Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest

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  3. The relationship between peak fat oxidation and prolonged double-poling endurance exercise performance

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  4. A Biological Age Model Designed for Health Promotion Interventions: Protocol for an Interdisciplinary Study for Model Development

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High-intensity interval training (HIT) is known to increase mitochondrial content in a similar way as endurance training [60-90% of maximal oxygen uptake (VO2peak)]. Whether HIT increases the mitochondria's ability to oxidize lipids is currently debated. We investigated the effect of HIT on mitochondrial fat oxidation in skeletal muscle and adipose tissue. Mitochondrial oxidative phosphorylation (OXPHOS) capacity, mitochondrial substrate sensitivity (K(m)(app)), and mitochondrial content were measured in skeletal muscle and adipose tissue in healthy overweight subjects before and after 6 weeks of HIT (three times per week at 298 ± 21 W). HIT significantly increased VO2peak from 2.9 ± 0.2 to 3.1 ± 0.2 L/min. No differences were seen in maximal fat oxidation in either skeletal muscle or adipose tissue. K(m)(app) for octanoyl carnitine or palmitoyl carnitine were similar after training in skeletal muscle and adipose tissue. Maximal OXPHOS capacity with complex I- and II-linked substrates was increased after training in skeletal muscle but not in adipose tissue. In conclusion, 6 weeks of HIT increased VO2peak. Mitochondrial content and mitochondrial OXPHOS capacity were increased in skeletal muscle, but not in adipose tissue. Furthermore, mitochondrial fat oxidation was not improved in either skeletal muscle or adipose tissue.

Original languageEnglish
JournalScandinavian journal of medicine & science in sports
Volume25
Issue number1
Pages (from-to)e59-69
ISSN0905-7188
DOIs
Publication statusPublished - Feb 2015

    Research areas

  • Adult, Carnitine, Exercise, Female, Humans, Male, Mitochondria, Mitochondria, Muscle, Muscle, Skeletal, Overweight, Oxidative Phosphorylation, Oxygen Consumption, Palmitoylcarnitine, Subcutaneous Fat, Journal Article

ID: 51615561