Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer: a randomised trial (GERICO)

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mendelian randomisation study of smoking exposure in relation to breast cancer risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment

    Research output: Contribution to journalEditorialResearchpeer-review

  3. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Clinical presentation and mortality in hospitalized patients aged 80+ years with COVID-19-A retrospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The risk of cardiac events in patients receiving immune checkpoint inhibitors: a nationwide Danish study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Perspective: targeting VEGF-A and YKL-40 in glioblastoma - matter matters

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Older patients with colorectal cancer (CRC) experience chemotherapy dose reductions or discontinuation. Comprehensive geriatric assessment (CGA) predicts survival and chemotherapy completion in patients with cancer, but the benefit of geriatric interventions remains unexplored. Methods: The GERICO study is a randomised Phase 3 trial including patients ≥70 years receiving adjuvant or first-line palliative chemotherapy for CRC. Vulnerable patients (G8 questionnaire ≤14 points) were randomised 1:1 to CGA-based interventions or standard care, along with guideline-based chemotherapy. The primary outcome was chemotherapy completion without dose reductions or delays. Secondary outcomes were toxicity, survival and quality of life (QoL). Results: Of 142 patients, 58% received adjuvant and 42% received first-line palliative chemotherapy. Interventions included medication changes (62%), nutritional therapy (51%) and physiotherapy (39%). More interventional patients completed scheduled chemotherapy compared with controls (45% vs. 28%, P = 0.0366). Severe toxicity occurred in 39% of controls and 28% of interventional patients (P = 0.156). QoL improved in interventional patients compared with controls with the decreased burden of illness (P = 0.048) and improved mobility (P = 0.008). Conclusion: Geriatric interventions compared with standard care increased the number of older, vulnerable patients with CRC completing adjuvant chemotherapy, and may improve the burden of illness and mobility. Trial registration: ClinicalTrials.gov ID: NCT 02748811.

Original languageEnglish
JournalBritish Journal of Cancer
Volume124
Issue number12
Pages (from-to)1949–1958
Number of pages10
ISSN0007-0920
DOIs
Publication statusPublished - Jun 2021

ID: 66211140