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The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: a randomized crossover trial

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@article{c05fe156bab7492ab612c18d03790128,
title = "The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: a randomized crossover trial",
abstract = "OBJECTIVE: The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure.MATERIALS/METHODS: Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23.4; 38.3) years; BMI, 31.9 ± 6.7 kg/m2; VO2max*, 39.5 (38.8; 40.9) ml/min/kg; HbA1c, 5.3 ± 0.4{\%} (34.1 ± 4.2 mmol/mol); mean ± SD (*median (25th; 75th percentile)) completed four 8-h interventions in randomized order: 1) uninterrupted sitting (SIT), 2) sitting interrupted by 2 min of walking (~30{\%} of VO2max) every 20th minute (INT20), 3) sitting interrupted by 6 min of walking every hour (INT60), and 4) sitting interrupted by 12 min of walking every second hour (INT120). A standardized test drink was served at the beginning of and four hours into the intervention (total of 2310 ± 247 kcal; 50{\%} energy from carbohydrate, 50{\%} energy from fat). Outcomes included the difference in the 8-h total area under the curve (tAUC) for primarily plasma glucose, and secondarily plasma insulin and C-peptide during INT20, INT60, and INT120 compared to SIT.RESULTS: No difference [95{\%} CI] was observed in the primary outcome, the 8-h tAUC for the plasma glucose, during INT20, INT60, and INT120 compared to SIT (-65.3 mmol/l*min [-256.3; 125.7], +53.8 mmol/l*min [-143.1; 250.8], and + 18.6 mmol/l*min [-172.4; 209.6], respectively).CONCLUSIONS: Interrupting sitting with increasing frequency did not reduce the postprandial plasma glucose response to prolonged sitting in healthy, sedentary, centrally obese men.",
author = "Thorsen, {Ida K} and Johansen, {Mette Y} and Pilmark, {Nanna S} and Jespersen, {Naja Z} and Brinkl{\o}v, {Cecilie F} and Benatti, {Fabiana B} and Dunstan, {David W} and Kristian Karstoft and Pedersen, {Bente K} and Mathias Ried-Larsen",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "4",
day = "4",
doi = "10.1016/j.metabol.2019.04.003",
language = "English",
journal = "Metabolism",
issn = "0026-0495",
publisher = "W.B./Saunders Co",

}

RIS

TY - JOUR

T1 - The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism

T2 - a randomized crossover trial

AU - Thorsen, Ida K

AU - Johansen, Mette Y

AU - Pilmark, Nanna S

AU - Jespersen, Naja Z

AU - Brinkløv, Cecilie F

AU - Benatti, Fabiana B

AU - Dunstan, David W

AU - Karstoft, Kristian

AU - Pedersen, Bente K

AU - Ried-Larsen, Mathias

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/4/4

Y1 - 2019/4/4

N2 - OBJECTIVE: The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure.MATERIALS/METHODS: Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23.4; 38.3) years; BMI, 31.9 ± 6.7 kg/m2; VO2max*, 39.5 (38.8; 40.9) ml/min/kg; HbA1c, 5.3 ± 0.4% (34.1 ± 4.2 mmol/mol); mean ± SD (*median (25th; 75th percentile)) completed four 8-h interventions in randomized order: 1) uninterrupted sitting (SIT), 2) sitting interrupted by 2 min of walking (~30% of VO2max) every 20th minute (INT20), 3) sitting interrupted by 6 min of walking every hour (INT60), and 4) sitting interrupted by 12 min of walking every second hour (INT120). A standardized test drink was served at the beginning of and four hours into the intervention (total of 2310 ± 247 kcal; 50% energy from carbohydrate, 50% energy from fat). Outcomes included the difference in the 8-h total area under the curve (tAUC) for primarily plasma glucose, and secondarily plasma insulin and C-peptide during INT20, INT60, and INT120 compared to SIT.RESULTS: No difference [95% CI] was observed in the primary outcome, the 8-h tAUC for the plasma glucose, during INT20, INT60, and INT120 compared to SIT (-65.3 mmol/l*min [-256.3; 125.7], +53.8 mmol/l*min [-143.1; 250.8], and + 18.6 mmol/l*min [-172.4; 209.6], respectively).CONCLUSIONS: Interrupting sitting with increasing frequency did not reduce the postprandial plasma glucose response to prolonged sitting in healthy, sedentary, centrally obese men.

AB - OBJECTIVE: The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure.MATERIALS/METHODS: Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23.4; 38.3) years; BMI, 31.9 ± 6.7 kg/m2; VO2max*, 39.5 (38.8; 40.9) ml/min/kg; HbA1c, 5.3 ± 0.4% (34.1 ± 4.2 mmol/mol); mean ± SD (*median (25th; 75th percentile)) completed four 8-h interventions in randomized order: 1) uninterrupted sitting (SIT), 2) sitting interrupted by 2 min of walking (~30% of VO2max) every 20th minute (INT20), 3) sitting interrupted by 6 min of walking every hour (INT60), and 4) sitting interrupted by 12 min of walking every second hour (INT120). A standardized test drink was served at the beginning of and four hours into the intervention (total of 2310 ± 247 kcal; 50% energy from carbohydrate, 50% energy from fat). Outcomes included the difference in the 8-h total area under the curve (tAUC) for primarily plasma glucose, and secondarily plasma insulin and C-peptide during INT20, INT60, and INT120 compared to SIT.RESULTS: No difference [95% CI] was observed in the primary outcome, the 8-h tAUC for the plasma glucose, during INT20, INT60, and INT120 compared to SIT (-65.3 mmol/l*min [-256.3; 125.7], +53.8 mmol/l*min [-143.1; 250.8], and + 18.6 mmol/l*min [-172.4; 209.6], respectively).CONCLUSIONS: Interrupting sitting with increasing frequency did not reduce the postprandial plasma glucose response to prolonged sitting in healthy, sedentary, centrally obese men.

U2 - 10.1016/j.metabol.2019.04.003

DO - 10.1016/j.metabol.2019.04.003

M3 - Journal article

JO - Metabolism

JF - Metabolism

SN - 0026-0495

ER -

ID: 56957772