Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: a randomized crossover trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes - Results from the EPICOM study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Vagotomy and subsequent development of diabetes - A nested case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effects of dapagliflozin, metformin or exercise on glucose metabolism and glycaemic variability in individuals with prediabetes: The PRE-D trial

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  2. Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effects of Dapagliflozin, Metformin or Exercise on Glucose Metabolism in Individuals with Prediabetes: The PRE-D Trial

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. Effects of Dapagliflozin, Metformin or Exercise on Markers of Cardiometabolic Risk: The PRE-D Trial

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  5. Effects of Dapagliflozin, Metformin or Exercise on Glycaemic Variability and Mean Glucose Levels in Prediabetes: The PRE-D Trial

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

View graph of relations

OBJECTIVE: The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure.

MATERIALS/METHODS: Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23.4; 38.3) years; BMI, 31.9 ± 6.7 kg/m2; VO2max*, 39.5 (38.8; 40.9) ml/min/kg; HbA1c, 5.3 ± 0.4% (34.1 ± 4.2 mmol/mol); mean ± SD (*median (25th; 75th percentile)) completed four 8-h interventions in randomized order: 1) uninterrupted sitting (SIT), 2) sitting interrupted by 2 min of walking (~30% of VO2max) every 20th minute (INT20), 3) sitting interrupted by 6 min of walking every hour (INT60), and 4) sitting interrupted by 12 min of walking every second hour (INT120). A standardized test drink was served at the beginning of and four hours into the intervention (total of 2310 ± 247 kcal; 50% energy from carbohydrate, 50% energy from fat). Outcomes included the difference in the 8-h total area under the curve (tAUC) for primarily plasma glucose, and secondarily plasma insulin and C-peptide during INT20, INT60, and INT120 compared to SIT.

RESULTS: No difference [95% CI] was observed in the primary outcome, the 8-h tAUC for the plasma glucose, during INT20, INT60, and INT120 compared to SIT (-65.3 mmol/l*min [-256.3; 125.7], +53.8 mmol/l*min [-143.1; 250.8], and + 18.6 mmol/l*min [-172.4; 209.6], respectively).

CONCLUSIONS: Interrupting sitting with increasing frequency did not reduce the postprandial plasma glucose response to prolonged sitting in healthy, sedentary, centrally obese men.

Original languageEnglish
JournalMetabolism: Clinical and Experimental
ISSN0026-0495
DOIs
Publication statusE-pub ahead of print - 4 Apr 2019

ID: 56957772