The effect of ferritin-guided iron supplementation among Danish female first-time blood donors

Louise Ørnskov Drechsler; Jens Kjaergaard Boldsen; Lotte Hindhede; Bitten Aagaard; Lene Holm Harritshøj; Christina Mikkelsen; Thorsten Brodersen; Nanna Brøns; Michael Schwinn; Henrik Hjalgrim; Klaus Rostgaard; Mie Topholm Bruun; Sisse Rye Ostrowski; Ole Birger Pedersen; Susan Mikkelsen; Christian Erikstrup

doi:10.1111/trf.17484

The effect of ferritin-guided iron supplementation among Danish female first-time blood donors

Louise Ørnskov Drechsler^*, Jens Kjaergaard Boldsen, Lotte Hindhede, Bitten Aagaard, Lene Holm Harritshøj, Christina Mikkelsen, Thorsten Brodersen, Nanna Brøns, Michael Schwinn, Henrik Hjalgrim, Klaus Rostgaard, Mie Topholm Bruun, Sisse Rye Ostrowski, Ole Birger Pedersen, Susan Mikkelsen, Christian Erikstrup

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

BACKGROUND: The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark.

STUDY DESIGN AND METHODS: We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period.

RESULTS: We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71-0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02-1.08.

DISCUSSION: Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.

Original language	English
Journal	Transfusion
Volume	63
Issue number	9
Pages (from-to)	1710-1718
Number of pages	9
ISSN	0041-1132
DOIs	https://doi.org/10.1111/trf.17484
Publication status	Published - Sept 2023

Keywords

Humans
Female
Iron
Ferritins
Blood Donors
Hemoglobins/analysis
Dietary Supplements
Denmark
ferritin
iron supplementation
hemoglobin
blood donation

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10.1111/trf.17484

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Drechsler, L. Ø., Boldsen, J. K., Hindhede, L., Aagaard, B., Harritshøj, L. H., Mikkelsen, C., Brodersen, T., Brøns, N., Schwinn, M., Hjalgrim, H., Rostgaard, K., Topholm Bruun, M., Ostrowski, S. R., Pedersen, O. B., Mikkelsen, S., & Erikstrup, C. (2023). The effect of ferritin-guided iron supplementation among Danish female first-time blood donors. Transfusion, 63(9), 1710-1718. https://doi.org/10.1111/trf.17484

Drechsler, LØ, Boldsen, JK, Hindhede, L, Aagaard, B, Harritshøj, LH, Mikkelsen, C, Brodersen, T, Brøns, N , Schwinn, M , Hjalgrim, H, Rostgaard, K, Topholm Bruun, M, Ostrowski, SR, Pedersen, OB, Mikkelsen, S & Erikstrup, C 2023, 'The effect of ferritin-guided iron supplementation among Danish female first-time blood donors', Transfusion, vol. 63, no. 9, pp. 1710-1718. https://doi.org/10.1111/trf.17484

@article{4aefd282924b4b3b9b81252a046c6aed,

title = "The effect of ferritin-guided iron supplementation among Danish female first-time blood donors",

abstract = "BACKGROUND: The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark.STUDY DESIGN AND METHODS: We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L \textasciitilde{} 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period.RESULTS: We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95\% confidence interval (CI), 0.71-0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95\% CI: 1.02-1.08.DISCUSSION: Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.",

keywords = "Humans, Female, Iron, Ferritins, Blood Donors, Hemoglobins/analysis, Dietary Supplements, Denmark, ferritin, iron supplementation, hemoglobin, blood donation",

author = "Drechsler, \{Louise {\O}rnskov\} and Boldsen, \{Jens Kjaergaard\} and Lotte Hindhede and Bitten Aagaard and Harritsh{\o}j, \{Lene Holm\} and Christina Mikkelsen and Thorsten Brodersen and Nanna Br{\o}ns and Michael Schwinn and Henrik Hjalgrim and Klaus Rostgaard and \{Topholm Bruun\}, Mie and Ostrowski, \{Sisse Rye\} and Pedersen, \{Ole Birger\} and Susan Mikkelsen and Christian Erikstrup",

note = "{\textcopyright} 2023 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.",

year = "2023",

month = sep,

doi = "10.1111/trf.17484",

language = "English",

volume = "63",

pages = "1710--1718",

journal = "Transfusion",

issn = "0041-1132",

publisher = "John Wiley and Sons Inc.",

number = "9",

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TY - JOUR

T1 - The effect of ferritin-guided iron supplementation among Danish female first-time blood donors

AU - Drechsler, Louise Ørnskov

AU - Boldsen, Jens Kjaergaard

AU - Hindhede, Lotte

AU - Aagaard, Bitten

AU - Harritshøj, Lene Holm

AU - Mikkelsen, Christina

AU - Brodersen, Thorsten

AU - Brøns, Nanna

AU - Schwinn, Michael

AU - Hjalgrim, Henrik

AU - Rostgaard, Klaus

AU - Topholm Bruun, Mie

AU - Ostrowski, Sisse Rye

AU - Pedersen, Ole Birger

AU - Mikkelsen, Susan

AU - Erikstrup, Christian

PY - 2023/9

Y1 - 2023/9

N2 - BACKGROUND: The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark.STUDY DESIGN AND METHODS: We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period.RESULTS: We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71-0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02-1.08.DISCUSSION: Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.

AB - BACKGROUND: The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark.STUDY DESIGN AND METHODS: We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period.RESULTS: We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71-0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02-1.08.DISCUSSION: Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.

KW - Humans

KW - Female

KW - Iron

KW - Ferritins

KW - Blood Donors

KW - Hemoglobins/analysis

KW - Dietary Supplements

KW - Denmark

KW - ferritin

KW - iron supplementation

KW - hemoglobin

KW - blood donation

UR - https://www.scopus.com/pages/publications/85165303551

U2 - 10.1111/trf.17484

DO - 10.1111/trf.17484

M3 - Journal article

C2 - 37452554

SN - 0041-1132

VL - 63

SP - 1710

EP - 1718

JO - Transfusion

JF - Transfusion

IS - 9

ER -

The effect of ferritin-guided iron supplementation among Danish female first-time blood donors

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