The Effect of Exercise on Quality of Life in Patients With Advanced Lung Cancer: A Secondary Analysis of a Randomized Controlled Trial

Zina Bloch; Sandra Jensen; Victor Sørensen; Seppo W Langer; Morten Quist

doi:10.1016/j.cllc.2025.07.005

The Effect of Exercise on Quality of Life in Patients With Advanced Lung Cancer: A Secondary Analysis of a Randomized Controlled Trial

Zina Bloch, Sandra Jensen, Victor Sørensen, Seppo W Langer, Morten Quist^*

^*Corresponding author for this work

5 Citations (Scopus)

Abstract

Microabstract This exploratory study evaluated a 12-week exercise program in 218 patients with advanced lung cancer receiving chemotherapy. Compared to usual care, exercise stabilized neuropathy and significantly reduced pain (EORTC QLQ-C30/LC13), while neuropathy worsened in controls. Findings suggest exercise may help preserve health-related quality of life during chemotherapy and support its role in lung cancer care.

Original language	English
Journal	Clinical Lung Cancer
Volume	26
Issue number	7
Pages (from-to)	e582-e590
ISSN	1525-7304
DOIs	https://doi.org/10.1016/j.cllc.2025.07.005
Publication status	Published - Nov 2025

Keywords

Aged
Exercise
Exercise Therapy/methods
Female
Humans
Lung Neoplasms/therapy
Male
Middle Aged
Quality of Life
Surveys and Questionnaires

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10.1016/j.cllc.2025.07.005Licence: CC BY

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title = "The Effect of Exercise on Quality of Life in Patients With Advanced Lung Cancer: A Secondary Analysis of a Randomized Controlled Trial",

abstract = "Microabstract This exploratory study evaluated a 12-week exercise program in 218 patients with advanced lung cancer receiving chemotherapy. Compared to usual care, exercise stabilized neuropathy and significantly reduced pain (EORTC QLQ-C30/LC13), while neuropathy worsened in controls. Findings suggest exercise may help preserve health-related quality of life during chemotherapy and support its role in lung cancer care.",

keywords = "Aged, Exercise, Exercise Therapy/methods, Female, Humans, Lung Neoplasms/therapy, Male, Middle Aged, Quality of Life, Surveys and Questionnaires",

author = "Zina Bloch and Sandra Jensen and Victor S{\o}rensen and Langer, \{Seppo W\} and Morten Quist",

year = "2025",

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doi = "10.1016/j.cllc.2025.07.005",

language = "English",

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T1 - The Effect of Exercise on Quality of Life in Patients With Advanced Lung Cancer

T2 - A Secondary Analysis of a Randomized Controlled Trial

AU - Bloch, Zina

AU - Jensen, Sandra

AU - Sørensen, Victor

AU - Langer, Seppo W

AU - Quist, Morten

PY - 2025/11

Y1 - 2025/11

N2 - Microabstract This exploratory study evaluated a 12-week exercise program in 218 patients with advanced lung cancer receiving chemotherapy. Compared to usual care, exercise stabilized neuropathy and significantly reduced pain (EORTC QLQ-C30/LC13), while neuropathy worsened in controls. Findings suggest exercise may help preserve health-related quality of life during chemotherapy and support its role in lung cancer care.

AB - Microabstract This exploratory study evaluated a 12-week exercise program in 218 patients with advanced lung cancer receiving chemotherapy. Compared to usual care, exercise stabilized neuropathy and significantly reduced pain (EORTC QLQ-C30/LC13), while neuropathy worsened in controls. Findings suggest exercise may help preserve health-related quality of life during chemotherapy and support its role in lung cancer care.

KW - Aged

KW - Exercise

KW - Exercise Therapy/methods

KW - Female

KW - Humans

KW - Lung Neoplasms/therapy

KW - Male

KW - Middle Aged

KW - Quality of Life

KW - Surveys and Questionnaires

UR - https://www.scopus.com/pages/publications/105012774137

U2 - 10.1016/j.cllc.2025.07.005

DO - 10.1016/j.cllc.2025.07.005

M3 - Journal article

C2 - 40750479

SN - 1525-7304

VL - 26

SP - e582-e590

JO - Clinical Lung Cancer

JF - Clinical Lung Cancer

IS - 7

ER -

The Effect of Exercise on Quality of Life in Patients With Advanced Lung Cancer: A Secondary Analysis of a Randomized Controlled Trial

Abstract

Keywords

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