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The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats

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  1. Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorder

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  2. Melatonin and cortisol profiles in the absence of light perception

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  1. Electroconvulsive therapy, depression severity and mortality: Data from the Danish National Patient Registry

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  2. The impact of mental vulnerability on the relationship between cardiovascular disease and depression

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  3. Trajectory of cognitive functions in bipolar disorder: for better or worse?

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  4. Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

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Electroconvulsive therapy (ECT) is the most effective and fast-acting treatment for severe depression but associated with troublesome cognitive side-effects. Systemically administered erythropoietin (EPO) crosses the blood-brain-barrier and is a promising treatment for cognitive dysfunction in a wide array of neuropsychiatric and neurological disorders. In this study we trained rats to locate a submerged platform in a water maze and then subjected them to electroconvulsive stimulations (ECS, the rodent equivalent to ECT) and EPO treatment. We then analysed their ability to remember and relearn the location of the platform. In addition, we examined "wall-clinging" (thigmotaxis), a behavioural indicator of stress. ECS caused significant deficit in a probe trial administered after three weeks (nine stimulations) as well as one week (six stimulations) of treatment, indicative of induction of retrograde amnesia. ECS had no effect on relearning of the water maze task or performance in a subsequent probe trial. EPO treatment did not ameliorate the ECS-induced retrograde amnesia, but after nine ECS stimulations the animals that had received EPO relearned the position of the hidden platform faster than the animals that had not. We also found EPO to decrease "wall-clinging" behaviour, suggesting an effect of EPO on the stress response in rats. Thus, we establish the Morris Water Maze as a suitable model for ECS-induced memory loss in rats and provide some evidence for potential beneficial effects of EPO.

Original languageEnglish
JournalBehavioural Brain Research
Volume382
Pages (from-to)112484
ISSN0166-4328
DOIs
Publication statusPublished - 16 Mar 2020

ID: 59449355