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The Effect of Different Comorbidities on Survival of Non-small Cells Lung Cancer Patients

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  1. Risk of chronic bronchitis in twin pairs discordant for smoking

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  2. Genetic Influences on Pulmonary Function: A Large Sample Twin Study

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  3. Downregulation of aquaporin-1 in alveolar microvessels in lungs adapted to chronic heart failure

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  1. AHRR (cg05575921) methylation extent of leukocyte DNA and lung cancer survival

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  2. Medicinsk behandling af lungecancer

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  3. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

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  4. Geographical variations in the use of cancer treatments are associated with survival of lung cancer patients

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  • Maria Iachina
  • Erik Jakobsen
  • Henrik Møller
  • Margreet Lüchtenborg
  • Anders Mellemgaard
  • Mark Krasnik
  • Anders Green
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PURPOSE: Primary lung cancer is one of the most common types of cancers. Comorbidity has been shown to be a negative prognostic factor in the overall lung cancer population. The significance of the individual comorbidities is less well known. The purpose of this paper is to investigate the effect of each comorbid disease groups on survival.

METHODS: The analysis is based on all patients with NSCLC who were registered in 2009-2011, in total 10,378 patients. To estimate the effect of each comorbidity group on the survival, we fitted a Cox regression model for each comorbidity group adjusting for age, sex, resection, and stage.

RESULTS: Patients with cardiovascular comorbidity have a 30 % higher death rate [HR 1.30 with 95 % CI (1.13; 1.49)] than patients without comorbidity. Patients with diabetes and patients with cerebrovascular disorders and COPD have a 20 % excess mortality than patients without comorbidity: [HR 1.19 with CI (1.02; 1.39) for diabetes, HR 1.18 with CI (1.05; 1.33) for cerebrovascular disorders, and HR 1.20 with CI (1.10; 1.39 for COPD)].

CONCLUSION: Our study shows the importance of cardiovascular disease in lung cancer. Diabetes, cerebrovascular disorders, and COPD also have a significant impact on survival of NSCLC patients.

Original languageEnglish
JournalLung
Volume193
Issue number2
Pages (from-to)291-297
Number of pages7
ISSN0341-2040
DOIs
Publication statusPublished - 17 Dec 2014

ID: 45090080