Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Developing and validating COVID-19 adverse outcome risk prediction models from a bi-national European cohort of 5594 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Isolation and characterisation of novel phages infecting Lactobacillus plantarum and proposal of a new genus, "Silenusvirus"

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Acute metabolic effects of melatonin - a randomized crossover study in healthy young men

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Trajectories of Childhood Adversity and Type 1 Diabetes: A Nationwide Study of One Million Children

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18-96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models.

Original languageEnglish
JournalScientific Reports
Volume10
Issue number1
Pages (from-to)22081
ISSN2045-2322
DOIs
Publication statusPublished - 16 Dec 2020

ID: 61613942