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The effect of cholecalciferol and calcitriol on biochemical bone markers in HIV type 1-infected males: results of a clinical trial

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HIV-1-infected patients have an increased risk of osteoporosis and fractures. The main objective of this study was to evaluate the bone metabolism in HIV-1-infected patients exposed to calcitriol and cholecalciferol. We also investigated the relationship between T cells and bone markers. We conducted a placebo-controlled randomized study running for 16 weeks including 61 HIV-1-infected males, of whom 51 completed the protocol. Nineteen participants were randomized to daily treatment with (A) 0.5-1.0 μg calcitriol and 1,200 IU (30 μg) cholecalciferol, 17 participants to (B) 1,200 IU cholecalciferol, and 15 participants to (C) placebo. At baseline and after 16 weeks, we determined collagen type 1 trimeric cross-linked peptide (CTx), procollagen type 1 N-terminal peptide (P1NP), parathyroid hormone (PTH), ionized calcium, 25-hydroxyvitamin D (25OHD), and 1,25-dihydroxyvitamin D [1,25(OH)2D]. We determined naive CD4(+) and CD8(+), activated CD4(+) and CD8(+), and regulatory CD4(+)CD25(+)CD127(low) T lymphocytes. Baseline levels of P1NP and CTx correlated (coefficient 0.5, p
Original languageEnglish
JournalAIDS Research and Human Retroviruses
Issue number4
Pages (from-to)658-64
Number of pages7
Publication statusPublished - Apr 2013

    Research areas

  • Adult, Biological Markers, Bone Density Conservation Agents, Bone and Bones, Calcitriol, Calcium, Cholecalciferol, Collagen Type I, Double-Blind Method, HIV Infections, HIV-1, Humans, Male, Middle Aged, Osteogenesis, Parathyroid Hormone, Peptide Fragments, Peptides, Procollagen, Prospective Studies, T-Lymphocyte Subsets, Vitamin D

ID: 41168763