Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Duffy-null genotype and risk of infection

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Functional Assessment of Variants Associated with Wolfram Syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Consortium-based genome-wide meta-analysis for childhood dental caries traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Detection of illness worry in the general population: A specific item on illness rumination improves the Whiteley Index

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effectiveness of cognitive remediation in the ultra-high risk state for psychosis

    Research output: Contribution to journalLetterResearchpeer-review

  4. Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Many medical treatments, from oncology to psychiatry, can lower white blood cell counts and thus access to these treatments can be restricted to individuals with normal levels of white blood cells, principally in order to minimise risk of serious infection. This adversely affects individuals of African or Middle Eastern ancestries who have on average a reduced number of circulating white blood cells, due to the Duffy-null (CC) genotype at rs2814778 in the ACKR1 gene. Here, we investigate whether the Duffy-null genotype is associated with the risk of infection using the UK Biobank sample and the iPSYCH Danish case-cohort study, two population-based samples from different countries and age ranges. We found that a high proportion of those with the Duffy-null genotype (21%) had a neutrophil count below the threshold often used as a cut-off for access to relevant treatments, compared to 1% of those with the TC/TT genotype. In addition we found that despite its strong association with lower average neutrophil counts, the Duffy-null genotype was not associated with an increased risk of infection, viral or bacterial. These results have widespread implications for the clinical treatment of individuals of African ancestry and indicate that that neutrophil thresholds to access treatments could be lowered in individuals with the Duffy-null genotype without an increased risk of infection.

Original languageEnglish
JournalHuman Molecular Genetics
ISSN0964-6906
DOIs
Publication statusPublished - 22 Sep 2020

ID: 60906058