Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Duffy-null genotype and risk of infection

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Functional Assessment of Variants Associated with Wolfram Syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Consortium-based genome-wide meta-analysis for childhood dental caries traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Many medical treatments, from oncology to psychiatry, can lower white blood cell counts and thus access to these treatments can be restricted to individuals with normal levels of white blood cells, principally in order to minimize risk of serious infection. This adversely affects individuals of African or Middle Eastern ancestries who have on average a reduced number of circulating white blood cells, because of the Duffy-null (CC) genotype at rs2814778 in the ACKR1 gene. Here, we investigate whether the Duffy-null genotype is associated with the risk of infection using the UK Biobank sample and the iPSYCH Danish case-cohort study, two population-based samples from different countries and age ranges. We found that a high proportion of those with the Duffy-null genotype (21%) had a neutrophil count below the threshold often used as a cut-off for access to relevant treatments, compared with 1% of those with the TC/TT genotype. In addition we found that despite its strong association with lower average neutrophil counts, the Duffy-null genotype was not associated with an increased risk of infection, viral or bacterial. These results have widespread implications for the clinical treatment of individuals of African ancestry and indicate that neutrophil thresholds to access treatments could be lowered in individuals with the Duffy-null genotype without an increased risk of infection.

Original languageEnglish
JournalHuman Molecular Genetics
Volume29
Issue number20
Pages (from-to)3341-3349
Number of pages9
ISSN0964-6906
DOIs
Publication statusPublished - 18 Dec 2020

ID: 60906058