The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas

Zarah Glad Zimling; Anne  Jørgensen; Eric Santoni-Rugiu

doi:10.1111/j.1365-2559.2012.04196.x

The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas

Zarah Glad Zimling, Anne Jørgensen, Eric Santoni-Rugiu

Department of Pathology

20 Citations (Scopus)

Abstract

Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.

Original language	English
Journal	Histopathology
Volume	60
Issue number	6B
Pages (from-to)	E96-105
ISSN	0309-0167
DOIs	https://doi.org/10.1111/j.1365-2559.2012.04196.x
Publication status	Published - 2012

Keywords

Humans
Immunohistochemistry
Mesothelioma
Pleural Neoplasms
Purine-Nucleoside Phosphorylase
Tumor Markers, Biological

Access to Document

10.1111/j.1365-2559.2012.04196.x

Cite this

@article{9f678ef2f5e846dc8888fad1125b5239,

title = "The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas",

abstract = " Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.",

keywords = "Humans, Immunohistochemistry, Mesothelioma, Pleural Neoplasms, Purine-Nucleoside Phosphorylase, Tumor Markers, Biological",

author = "Zimling, {Zarah Glad} and Anne J{\o}rgensen and Eric Santoni-Rugiu",

note = "{\textcopyright} 2012 Blackwell Publishing Ltd.",

year = "2012",

doi = "10.1111/j.1365-2559.2012.04196.x",

language = "English",

volume = "60",

pages = "E96--105",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6B",

}

TY - JOUR

T1 - The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas

AU - Zimling, Zarah Glad

AU - Jørgensen, Anne

AU - Santoni-Rugiu, Eric

PY - 2012

Y1 - 2012

N2 - Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.

AB - Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.

KW - Humans

KW - Immunohistochemistry

KW - Mesothelioma

KW - Pleural Neoplasms

KW - Purine-Nucleoside Phosphorylase

KW - Tumor Markers, Biological

U2 - 10.1111/j.1365-2559.2012.04196.x

DO - 10.1111/j.1365-2559.2012.04196.x

M3 - Journal article

C2 - 22394205

SN - 0309-0167

VL - 60

SP - E96-105

JO - Histopathology

JF - Histopathology

IS - 6B

ER -

The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas

Abstract

Keywords

Access to Document

Fingerprint

Cite this