Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The diagnostic accuracy of carcinoembryonic antigen to detect colorectal cancer recurrence - A systematic review

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{e0259e45624041319573a6c3e4be9549,
title = "The diagnostic accuracy of carcinoembryonic antigen to detect colorectal cancer recurrence - A systematic review",
abstract = "INTRODUCTION: Carcinoembryonic Antigen (CEA) has been used as a tumor marker in the follow-up of colorectal cancer for more than 40 years. Controversy exists regarding its diagnostic applicability due to a relatively low sensitivity and a questionable effect on mortality. The aim of this review was to assess the diagnostic accuracy of CEA in detecting recurrence after intended curative surgery for primary colorectal cancer.METHODS: Systematic literature searches were performed in PubMed, EMBASE and Cochrane databases, and articles were chosen based on predefined inclusion criteria. Reference lists from included articles were manually searched for additional publications of relevance.RESULTS: Forty-two original studies with generally representative populations and long follow-up were included. Data were reported on outcomes from 9,834 CEA tests during follow-up. Reporting on the reference standards used was not optimal. Sensitivity of CEA ranged from 17.4 {\%} to 100 {\%}, specificity ranged from 66.1 {\%} to 98.4 {\%}, positive predictive value ranged from 45.8 {\%} to 95.2{\%} and negative predictive value ranged from 74.5 {\%} to 100 {\%}.CONCLUSION: Results point toward a sensitivity of CEA ranging between 50 {\%} and 80 {\%}, and a specificity and negative predictive value above 80 {\%}. Results on positive predictive value showed low reliability. Overall, CEA did not effectively detect treatable recurrences at an early stage, and a clinically relevant effect on patient mortality remains to be proven.",
author = "Caspar S{\o}rensen and Karlsson, {William K} and Hans-Christian Pommergaard and Jakob Burcharth and Jacob Rosenberg",
note = "Copyright {\circledC} 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.",
year = "2016",
month = "1",
doi = "10.1016/j.ijsu.2015.11.065",
language = "English",
volume = "25",
pages = "134--144",
journal = "International Journal of Surgery",
issn = "1743-9191",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - The diagnostic accuracy of carcinoembryonic antigen to detect colorectal cancer recurrence - A systematic review

AU - Sørensen, Caspar

AU - Karlsson, William K

AU - Pommergaard, Hans-Christian

AU - Burcharth, Jakob

AU - Rosenberg, Jacob

N1 - Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

PY - 2016/1

Y1 - 2016/1

N2 - INTRODUCTION: Carcinoembryonic Antigen (CEA) has been used as a tumor marker in the follow-up of colorectal cancer for more than 40 years. Controversy exists regarding its diagnostic applicability due to a relatively low sensitivity and a questionable effect on mortality. The aim of this review was to assess the diagnostic accuracy of CEA in detecting recurrence after intended curative surgery for primary colorectal cancer.METHODS: Systematic literature searches were performed in PubMed, EMBASE and Cochrane databases, and articles were chosen based on predefined inclusion criteria. Reference lists from included articles were manually searched for additional publications of relevance.RESULTS: Forty-two original studies with generally representative populations and long follow-up were included. Data were reported on outcomes from 9,834 CEA tests during follow-up. Reporting on the reference standards used was not optimal. Sensitivity of CEA ranged from 17.4 % to 100 %, specificity ranged from 66.1 % to 98.4 %, positive predictive value ranged from 45.8 % to 95.2% and negative predictive value ranged from 74.5 % to 100 %.CONCLUSION: Results point toward a sensitivity of CEA ranging between 50 % and 80 %, and a specificity and negative predictive value above 80 %. Results on positive predictive value showed low reliability. Overall, CEA did not effectively detect treatable recurrences at an early stage, and a clinically relevant effect on patient mortality remains to be proven.

AB - INTRODUCTION: Carcinoembryonic Antigen (CEA) has been used as a tumor marker in the follow-up of colorectal cancer for more than 40 years. Controversy exists regarding its diagnostic applicability due to a relatively low sensitivity and a questionable effect on mortality. The aim of this review was to assess the diagnostic accuracy of CEA in detecting recurrence after intended curative surgery for primary colorectal cancer.METHODS: Systematic literature searches were performed in PubMed, EMBASE and Cochrane databases, and articles were chosen based on predefined inclusion criteria. Reference lists from included articles were manually searched for additional publications of relevance.RESULTS: Forty-two original studies with generally representative populations and long follow-up were included. Data were reported on outcomes from 9,834 CEA tests during follow-up. Reporting on the reference standards used was not optimal. Sensitivity of CEA ranged from 17.4 % to 100 %, specificity ranged from 66.1 % to 98.4 %, positive predictive value ranged from 45.8 % to 95.2% and negative predictive value ranged from 74.5 % to 100 %.CONCLUSION: Results point toward a sensitivity of CEA ranging between 50 % and 80 %, and a specificity and negative predictive value above 80 %. Results on positive predictive value showed low reliability. Overall, CEA did not effectively detect treatable recurrences at an early stage, and a clinically relevant effect on patient mortality remains to be proven.

U2 - 10.1016/j.ijsu.2015.11.065

DO - 10.1016/j.ijsu.2015.11.065

M3 - Journal article

VL - 25

SP - 134

EP - 144

JO - International Journal of Surgery

JF - International Journal of Surgery

SN - 1743-9191

ER -

ID: 45956271