The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

Niels Grarup; M Overvad; Thomas Hempel Sparsø; Daniel Rinse Witte; C Pisinger; T Jørgensen; T Yamauchi; K Hara; S Maeda; T Kadowaki; T Hansen; O Pedersen

doi:10.1007/s00125-010-2031-2

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

Niels Grarup, M Overvad, Thomas Hempel Sparsø, Daniel Rinse Witte, C Pisinger, T Jørgensen, T Yamauchi, K Hara, S Maeda, T Kadowaki, T Hansen, O Pedersen

30 Citations (Scopus)

Abstract

A genome-wide association study in the Japanese population reported two genome-wide significant loci associated with type 2 diabetes of which the VPS13C/C2CD4A/C2CD4B locus was replicated in Europeans. We looked for potential associations between the diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant and diabetes-related intermediary traits.

Original language	English
Journal	Diabetologia
Volume	54
Issue number	4
Pages (from-to)	789-94
Number of pages	6
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-010-2031-2
Publication status	Published - 2011

Keywords

Adult
Diabetes Mellitus, Type 2
Female
Genome-Wide Association Study
Genotype
Glucose
Glucose Tolerance Test
Humans
Insulin
Male
Middle Aged
Proteins

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10.1007/s00125-010-2031-2

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Grarup, N., Overvad, M., Sparsø, T. H., Witte, D. R., Pisinger, C., Jørgensen, T., Yamauchi, T., Hara, K., Maeda, S., Kadowaki, T., Hansen, T., & Pedersen, O. (2011). The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals. Diabetologia, 54(4), 789-94. https://doi.org/10.1007/s00125-010-2031-2

Grarup, N, Overvad, M, Sparsø, TH, Witte, DR, Pisinger, C , Jørgensen, T, Yamauchi, T, Hara, K, Maeda, S, Kadowaki, T, Hansen, T & Pedersen, O 2011, 'The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals', Diabetologia, vol. 54, no. 4, pp. 789-94. https://doi.org/10.1007/s00125-010-2031-2

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abstract = "A genome-wide association study in the Japanese population reported two genome-wide significant loci associated with type 2 diabetes of which the VPS13C/C2CD4A/C2CD4B locus was replicated in Europeans. We looked for potential associations between the diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant and diabetes-related intermediary traits.",

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AU - Overvad, M

AU - Sparsø, Thomas Hempel

AU - Witte, Daniel Rinse

AU - Pisinger, C

AU - Jørgensen, T

AU - Yamauchi, T

AU - Hara, K

AU - Maeda, S

AU - Kadowaki, T

AU - Hansen, T

AU - Pedersen, O

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KW - Diabetes Mellitus, Type 2

KW - Female

KW - Genome-Wide Association Study

KW - Genotype

KW - Glucose

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Proteins

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SP - 789

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IS - 4

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The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

Abstract

Keywords

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