The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery

Anne Benedicte Juul; Jørn Wetterslev; Allan Kofoed-Enevoldsen; Torben Callesen; Gorm Jensen; Christian Gluud; Diabetic Postoperative Mortality and Morbidity group

doi:10.1016/j.ahj.2003.10.030

The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery

Anne Benedicte Juul, Jørn Wetterslev, Allan Kofoed-Enevoldsen, Torben Callesen, Gorm Jensen, Christian Gluud, Diabetic Postoperative Mortality and Morbidity group

Copenhagen Trial Unit

59 Citations (Scopus)

Abstract

Recent trials suggest that perioperative beta-blockade reduces the risk of cardiac events in patients with a risk of myocardial ischemia who are undergoing noncardiac surgery. Patients with diabetes mellitus are at a high-risk for postoperative cardiac morbidity and mortality. They may, therefore, benefit from perioperative beta-blockade.

Original language	English
Journal	American Heart Journal
Volume	147
Issue number	4
Pages (from-to)	677-83
Number of pages	7
ISSN	0002-8703
DOIs	https://doi.org/10.1016/j.ahj.2003.10.030
Publication status	Published - Apr 2004

Keywords

Adrenergic beta-Antagonists
Adult
Aged
Aged, 80 and over
Diabetes Complications
Diabetes Mellitus
Female
Humans
Male
Metoprolol
Middle Aged
Multicenter Studies as Topic
Myocardial Ischemia
Outcome Assessment (Health Care)
Perioperative Care
Postoperative Complications
Randomized Controlled Trials as Topic
Research Design
Surgical Procedures, Operative

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Juul, A. B., Wetterslev, J., Kofoed-Enevoldsen, A., Callesen, T., Jensen, G., Gluud, C., & Diabetic Postoperative Mortality and Morbidity group (2004). The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery. American Heart Journal, 147(4), 677-83. https://doi.org/10.1016/j.ahj.2003.10.030

The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery. / Juul, Anne Benedicte; Wetterslev, Jørn; Kofoed-Enevoldsen, Allan et al.
In: American Heart Journal, Vol. 147, No. 4, 04.2004, p. 677-83.

Research output: Contribution to journal › Journal article › Research › peer-review

Juul, AB, Wetterslev, J, Kofoed-Enevoldsen, A, Callesen, T, Jensen, G, Gluud, C & Diabetic Postoperative Mortality and Morbidity group 2004, 'The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery', American Heart Journal, vol. 147, no. 4, pp. 677-83. https://doi.org/10.1016/j.ahj.2003.10.030

Juul AB, Wetterslev J, Kofoed-Enevoldsen A, Callesen T, Jensen G, Gluud C et al. The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery. American Heart Journal. 2004 Apr;147(4):677-83. doi: 10.1016/j.ahj.2003.10.030

Juul, Anne Benedicte ; Wetterslev, Jørn ; Kofoed-Enevoldsen, Allan et al. / The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial : rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery. In: American Heart Journal. 2004 ; Vol. 147, No. 4. pp. 677-83.

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abstract = "Recent trials suggest that perioperative beta-blockade reduces the risk of cardiac events in patients with a risk of myocardial ischemia who are undergoing noncardiac surgery. Patients with diabetes mellitus are at a high-risk for postoperative cardiac morbidity and mortality. They may, therefore, benefit from perioperative beta-blockade.",

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The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery

Abstract

Keywords

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