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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The density of knobs on Plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates

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The virulence of Plasmodium falciparum malaria is related to the parasite's ability to evade host immunity through clonal antigenic variation and tissue-specific adhesion of infected erythrocytes (IEs). The P. falciparum erythrocyte membrane protein 1 (PfEMP1) family expressed on dome-shaped protrusions called knobs on the IE surface is central to both. Differences in receptor specificity and affinity of expressed PfEMP1 are important for IE adhesiveness, but it is not known whether differences in the number and size of the knobs on which the PfEMP1 proteins are expressed also play a role. Therefore, the aim of this study was to provide detailed information on isolate- and time-dependent differences in knob size and density.
Original languageEnglish
JournalP L o S One
Volume7
Issue number9
Pages (from-to)e45658
ISSN1932-6203
DOIs
Publication statusPublished - 2012

ID: 36509610