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The day-to-day acute effect of wake therapy in patients with major depression using the HAM-D6 as primary outcome measure: results from a randomised controlled trial

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  1. Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome

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  2. Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

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  3. Dancing with atrial fibrillation - How arrhythmia affects everyday life of family members: A qualitative study

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  1. Seasonal variation in neurohormones, mood and sleep in patients with primary open angle glaucoma - implications of the ipRGC-system

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  2. Light therapy for seasonal affective disorder in visual impairment and blindness - a pilot study

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  3. Reducing the rate of psychiatric Re-ADMISsions in Bipolar Disorder using smartphones The RADMIS trial

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  4. Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation

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This paper reports day-to-day data for from a one-week intervention phase, part of a 9-weeks randomised parallel study with patient having major depression (data from weekly visits have been reported). Wake therapy (sleep deprivation) has an established antidepressant effect with onset of action within hours. Deterioration on the following night's sleep is, however, common, and we used daily light therapy and sleep time stabilisation as a preventive measure. In particular, we evaluated the day-to-day acute effect of and tolerance to sleep deprivation and examined predictors of response.
Original languageEnglish
JournalP L o S One
Volume8
Issue number6
Pages (from-to)e67264
ISSN1932-6203
DOIs
Publication statusPublished - 2013

ID: 42242420