Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Danish Fetal Medicine Database: Establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Borderline ovarian tumors in Denmark 1997-2018: Time trends in incidence by histology, age and educational level

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Differentiated timing of induction for women with intrahepatic cholestasis of pregnancy - a historical cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Length of hospital stay after cesarean section in Denmark from 2004 to 2016: a national register-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Female cigarette smoking and successful fertility treatment: a Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. SARS-CoV-2 in first trimester pregnancy: a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To describe establishment and organisation of the Danish Fetal Medicine Database and to report national results of first trimester combined screening for trisomy 21 in the five year period 2008-2012.

DESIGN: National register study using prospectively collected first trimester screening data from the Danish Fetal Medicine Database POPULATION: Pregnant women in Denmark undergoing first trimester screening for trisomy 21.

METHODS: Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First trimester screening data from 2008-2012 were retrieved. Main outcome measures Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates RESULTS: A total of 268 342 first trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82-90% in the 5-year period CONCLUSION: A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume94
Issue number6
Pages (from-to)577-583
ISSN0001-6349
DOIs
Publication statusPublished - Jun 2015

ID: 44938465