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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer

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BACKGROUND: Electrochemotherapy is an established treatment for cutaneous tumors. This study aimed at determining efficacy of electrochemotherapy in recurrent head and neck cancer.

METHODS: Phase II clinical trial in patients with recurrent head and neck carcinomas with no curative treatment options. Electrochemotherapy was performed under general anesthesia. Primary endpoint was tumor response (CT scanning) evaluated at week 8. Secondary endpoints included biopsy results, MRI and fluorodeoxyglucose-positron emission tomography scanning, safety, toxicity, pain score, and quality-of-life questionnaires.

RESULTS: Of 26 patients treated, 5 (19%) achieved complete response, 10 (39%) partial response, resulting in an objective response of 58%. Two responders remain without recurrence. No serious adverse events occurred during treatment. Four events occurred posttreatment: one bleeding episode, two episodes with mucosal swelling, and one patient died due to disease progression.

CONCLUSION: Electrochemotherapy is efficient against local recurrence of head and neck cancer with an overall response rate of 58%.

Original languageEnglish
JournalHead and Neck
Volume41
Issue number2
Pages (from-to)329-339
Number of pages11
ISSN1043-3074
DOIs
Publication statusPublished - Feb 2019

    Research areas

  • bleomycin, electrochemotherapy, electroporation, head and neck cancer, quality-of-life

ID: 56116766