TY - JOUR
T1 - The Copenhagen Oral Cavity Squamous Cell Carcinoma database
T2 - protocol and report on establishing a comprehensive oral cavity cancer database
AU - Schmidt Jensen, Jakob
AU - Jakobsen, Kathrine Kronberg
AU - Mirian, Christian
AU - Christensen, Julie Thor
AU - Schneider, Katrine
AU - Nahavandipour, Arvin
AU - Wingstrand, Vibe Lindeblad
AU - Wessel, Irene
AU - Tvedskov, Jesper Filtenborg
AU - Frisch, Thomas
AU - Christensen, Anders
AU - Specht, Lena
AU - Andersen, Elo
AU - Lelkaitis, Giedrius
AU - Grønhøj, Christian
AU - von Buchwald, Christian
N1 - © 2019 Schmidt Jensen et al.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective: The aim was to establish a large comprehensive database of patients with oral cavity squamous cell carcinoma (OSCC) to enable surveillance and research of the disease.Methods: All patients diagnosed and/or treated for OSCC at Rigshospitalet, University of Copenhagen, Denmark in the period 2000-2014 were included. Rigshospitalet is a tertiary treatment center and covers the Eastern Denmark region, comprising nearly half of the approximately 5.8 million inhabitants of Denmark. Data on numerous variables regarding general information of the patients at diagnosis, their primary cancer, recurrence, treatment, prior cancers, and secondary cancers were collected from the Danish Pathology Register and by evaluation of medical charts.Results: One thousand three hundred and ninety-nine OSCC patients were included in the database (62% males). The median age at diagnosis was 63 years (range: 23-99 years). The most common anatomical location was the floor of mouth (38%). Among patients with known stage, 70.0% were diagnosed in T-stage 1 or 2 and 64.9% were diagnosed in N-stage 0. Most patients were treated with primary surgery (81.7% among patients with known treatment), of these 44% received adjuvant radiotherapy after surgery. The overall age-standardized incidence of OSCC per 100,000 increased from 2.15 in 2000 to 3.04 in 2014, with a significant annual percent change of 3.2%.Conclusion: We have established a consecutive, population-based database of 1,399 OSCC patients. This creates a basis for multiple studies that will elaborate our understanding of OSCC, and hopefully improve diagnosis, treatment, and rehabilitation of OSCC patients.
AB - Objective: The aim was to establish a large comprehensive database of patients with oral cavity squamous cell carcinoma (OSCC) to enable surveillance and research of the disease.Methods: All patients diagnosed and/or treated for OSCC at Rigshospitalet, University of Copenhagen, Denmark in the period 2000-2014 were included. Rigshospitalet is a tertiary treatment center and covers the Eastern Denmark region, comprising nearly half of the approximately 5.8 million inhabitants of Denmark. Data on numerous variables regarding general information of the patients at diagnosis, their primary cancer, recurrence, treatment, prior cancers, and secondary cancers were collected from the Danish Pathology Register and by evaluation of medical charts.Results: One thousand three hundred and ninety-nine OSCC patients were included in the database (62% males). The median age at diagnosis was 63 years (range: 23-99 years). The most common anatomical location was the floor of mouth (38%). Among patients with known stage, 70.0% were diagnosed in T-stage 1 or 2 and 64.9% were diagnosed in N-stage 0. Most patients were treated with primary surgery (81.7% among patients with known treatment), of these 44% received adjuvant radiotherapy after surgery. The overall age-standardized incidence of OSCC per 100,000 increased from 2.15 in 2000 to 3.04 in 2014, with a significant annual percent change of 3.2%.Conclusion: We have established a consecutive, population-based database of 1,399 OSCC patients. This creates a basis for multiple studies that will elaborate our understanding of OSCC, and hopefully improve diagnosis, treatment, and rehabilitation of OSCC patients.
KW - database
KW - epidemiology
KW - head and neck cancer
KW - oral cavity cancer
KW - OSCC
KW - squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85073374627&partnerID=8YFLogxK
U2 - 10.2147/CLEP.S215399
DO - 10.2147/CLEP.S215399
M3 - Journal article
C2 - 31695503
SN - 1179-1349
VL - 11
SP - 733
EP - 741
JO - Clinical Epidemiology
JF - Clinical Epidemiology
ER -