Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The concentration of the cleaved suPAR forms in pre- and postoperative plasma samples improves the prediction of survival in colorectal cancer: A nationwide multicenter validation and discovery study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prognostic value of biochemical variables for survival after surgery for metastatic bone disease of the extremities

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Importance of margin width in breast-conserving treatment of early breast cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Improved survival with early adjuvant chemotherapy after colonic resection for stage III colonic cancer: A nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Laparoscopy to Assist Surgical Decisions Related to Necrotizing Enterocolitis in Preterm Neonates

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prognostic factors for relapse in patients with clinical stage I testicular cancer: Protocol for a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Optimized Biobanking Procedures for Preservation of RNA in Tissue: Comparison of Snap-Freezing and RNAlater-Fixation Methods

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Danish Collaborative Research Group on Colorectal Cancer
View graph of relations

Background and Objectives: The aim was to evaluate the prognostic biomarker potential of the soluble urokinase-type plasminogen activator receptor (suPAR) in plasma samples collected pre- and postoperatively from patients resected for colorectal cancer (CRC). Methods: Patients with CRC were recruited prospectively at six centers from 2006 to 2008. Preoperative plasma samples were available from 494 patients and from 328 of these patients at 6 months postoperatively. Determinations of intact soluble uPAR (suPAR) suPAR(I-III) and the cleaved forms suPAR(I-III) + (II-III) and uPAR(I) were performed. Clinical data were retrieved retrospectively. Results: In a multivariable model based on preoperative plasma samples suPAR(I-III) + (II-III) and uPAR(I) showed an independent statistically significant association to long term survival. When including the change in biomarker level between the pre- and postoperatively samples the hazard ratios were 3.06 (95% confidence interval [CI], 1.78-5.28; P <.0001) and 2.24 (95% CI, 1.59-3.16; P <.0001) for suPAR(I-III) + (II-III) and uPAR(I), respectively. A one-unit decrease in biomarker levels between the pre- and postoperative levels resulted in a 55% and 34% reduction in the risk estimate of death for suPAR(I-III) + (II-III) and uPAR(I), respectively. Conclusion: This study validates previously findings regarding the prognostic significance of suPAR in preoperative samples. The inclusion of postoperative samples added further prognostic information.

Original languageEnglish
JournalJournal of Surgical Oncology
Volume120
Issue number8
Pages (from-to)1404-1411
Number of pages8
ISSN0022-4790
DOIs
Publication statusPublished - Dec 2019

    Research areas

  • biomarkers, colorectal cancer, personalized medicine, Prognosis, Prospective Studies, Biomarkers, Tumor/blood, Humans, Middle Aged, Proportional Hazards Models, Male, Receptors, Urokinase Plasminogen Activator/blood, Denmark/epidemiology, Colorectal Neoplasms/blood, Aged, 80 and over, Adult, Female, Aged, Retrospective Studies

ID: 58214430