Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The circadian rhythm of calcium and bone homeostasis in Maasai

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Directly measured aerobic fitness in male Maasai of Tanzania

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Plasma marker for systemic inflammation is increased in Mexican Tarahumara following ultra-distance running

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Changes and correlations in height from 7 to 69 years of age across the birth years of 1930 to 1989

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Stable isotopes of carbon and nitrogen as markers of dietary variation among sociocultural subgroups of Inuit in Greenland

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Hemoglobin levels and blood pressure are associated in rural black africans

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Biochemical and clinical manifestations in adults with hypophosphatasia: a national cross-sectional study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Serum S100B protein after electroconvulsive therapy in patients with depression

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: Ethnic groups differ in prevalence of calcium-related diseases. Differences in the physiology and the endogenous circadian rhythm (CR) of calcium and bone homeostasis may play a role. Thus, we aimed to investigate details of CR pattern in calcium and bone homeostasis in East African Maasai.

METHODS: Ten clinically healthy adult Maasai men and women from Tanzania were examined. Blood samples were collected every 2nd hour for 24 h. Serum levels of total calcium, albumin, parathyroid hormone (PTH), 25(OH)D, creatinine, C-terminal telopeptide (CTX), bone-specific alkaline phosphatase (BSAP), procollagen type 1 N-terminal propeptide (P1NP), and osteocalcin were measured. Circadian patterns were derived from graphic curves of medians, and rhythmicity was assessed with Fourier analysis.

RESULTS: PTH-levels varied over the 24 h exhibiting a bimodal pattern. Nadir level corresponded to 65% of total 24-h mean. CTX and P1NP showed 24-h variations with a morning nadir and nocturnal peak with nadir levels corresponding to 23% and 79% of the 24-h mean, respectively. Albumin-corrected calcium level was held in a narrow range and alterations were corresponding to alterations in PTH. There was no distinct pattern in 24-h variations of 25(OH)D, creatinine, osteocalcin, or BSAP.

CONCLUSIONS: All participants showed pronounced 24-h variations in PTH and bone turnover markers CTX and P1NP. These findings support that Maasai participants included in this study have typical patterns of CR in calcium and bone homeostasis consistent with findings from other ethnic populations.

Original languageEnglish
Article numbere23756
JournalAmerican journal of human biology : the official journal of the Human Biology Council
Volume34
Issue number8
Pages (from-to)e23756
ISSN1042-0533
DOIs
Publication statusPublished - Aug 2022

Bibliographical note

© 2022 The Authors. American Journal of Human Biology published by Wiley Periodicals LLC.

    Research areas

  • Adult, Albumins, Biomarkers, Bone and Bones/physiology, Calcium/physiology, Circadian Rhythm/physiology, Creatinine, Ethnicity, Female, Homeostasis, Humans, Male, Osteocalcin, Parathyroid Hormone/physiology, Tanzania

ID: 77847419