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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The cardiac isovolumetric contraction time is an independent predictor of incident atrial fibrillation and adverse outcomes following first atrial fibrillation event in the general population

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DOI

  1. Left ventricular myocardial crypts: morphological patterns and prognostic implications

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Left ventricular trabeculation and major adverse cardiovascular events: the Copenhagen General Population Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Duration of early systolic lengthening: prognostic potential in the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

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AIMS: Colour tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise method to obtain cardiac time intervals including the isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT), and ejection time (ET). The myocardial performance index (MPI) was defined as [(IVCT + IVRT)/ET]. Our aim was to investigate if cardiac time intervals can be used to predict atrial fibrillation (AF) in the general population.

METHODS AND RESULTS: A total of 1915 participants from the general population underwent a health examination including TDI echocardiography. The primary endpoint was AF, and the secondary endpoint was complicated AF as assessed by the occurrence of either stroke or heart failure (HF) after the diagnosis of AF. Participants with known AF were excluded (n = 54). During a median follow-up of 11 years, 166 participants (9%) were diagnosed with AF and of these 44 participants (27%) developed HF or stroke. Assessing the association between IVCT and incident AF, the risk increased with 27% per 10 ms increase in IVCT [per 10 ms increase: hazard ratio (HR) 1.27, 95% confidence interval (CI) (1.17-1.38); P < 0.001]. The association remained significant after multivariable adjustment [per 10 ms increase: HR 1.22, 95% CI (1.09-1.35); P < 0.001]. No associations between the IVRT, ET, MPI, and AF remained significant after multivariable adjustment. The IVCT also predicted complicated AF and the association remained significant even after multivariable adjustment [per 10 ms increase: HR 1.39, 95% CI (1.06-1.81); P = 0.015].

CONCLUSION: In the general population, the IVCT provides novel and independent prognostic information on the long-term risk of AF. Additionally, the IVCT can identify persons in risk of complicated AF.

Original languageEnglish
JournalEuropean heart journal cardiovascular Imaging
Volume21
Issue number1
Pages (from-to)49-57
Number of pages9
ISSN1525-2167
DOIs
Publication statusPublished - 1 Jan 2020

ID: 59370290