The C24:0 Sulfatide Isoform as an Important Molecule in Type 1 Diabetes

Karsten Buschard*, Julie C Antvorskov

*Corresponding author for this work

Abstract

Particular molecules play pivotal roles in the pathogenesis of many autoimmune diseases. We suggest that the C24:0 sulfatide isoform may influence the development of type 1 diabetes (T1D). C24:0 sulfatide is a sphingolipid with a long carbon-atom chain. A C16:0 sulfatide isoform is also present in the insulin-producing beta cells of the islets of Langerhans. The C16:0 isoform exhibits chaperone activity and plays an important role in insulin production. In contrast, the C24:0 isoform may suppress the autoimmune attacks on beta cells that lead to T1D. Sphingolipid levels are reduced in individuals who later develop T1D but could be increased via dietary supplements or medication.

Original languageEnglish
Article number331
JournalFrontiers in bioscience (Landmark edition)
Volume27
Issue number12
Pages (from-to)331
ISSN2768-6698
DOIs
Publication statusPublished - 27 Dec 2022

Keywords

  • beta cells
  • C24:0 sulfatide
  • fenofibrate
  • pathogenesis
  • sulfatide
  • type 1 diabetes

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