The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease

Michael D Crowther; Andrew K Sewell

doi:10.1016/j.coi.2020.12.002

The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease

Center for Cancer Immune Therapy (CCIT)

Abstract

MR1 is a ubiquitously expressed, monomorphic antigen presenting molecule that has been largely preserved throughout mammalian evolution. The primary role of MR1 is to present conserved microbial metabolites to highly abundant mucosal-associated invariant T (MAIT) cells. The role of MAIT cells and other MR1-restricted T cells (MR1T) has been recently extended to immunomodulation during cancer. MR1Ts have also been implicated in autoimmune disease. The highly conserved nature of MR1 across the human population is in stark contrast to the MHC molecules recognised by conventional αβ T-cells, therefore MR1Ts may form fertile ground for the development of pan-population T-cell immunotherapeutics for a wide range of important morbidities.

Original language	English
Journal	Current Opinion in Immunology
Volume	69
Pages (from-to)	10-17
Number of pages	8
ISSN	0952-7915
DOIs	https://doi.org/10.1016/j.coi.2020.12.002
Publication status	Published - Apr 2021

Keywords

Animals
Antigen Presentation
Autoimmune Diseases/immunology
HLA Antigens/genetics
Histocompatibility Antigens Class I/metabolism
Humans
Immunotherapy, Adoptive/methods
Infections/immunology
Minor Histocompatibility Antigens/metabolism
Mucosal-Associated Invariant T Cells/immunology
Neoplasms/immunology
Receptors, Antigen, T-Cell, alpha-beta/genetics
T-Lymphocytes/immunology

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10.1016/j.coi.2020.12.002

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title = "The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease",

abstract = "MR1 is a ubiquitously expressed, monomorphic antigen presenting molecule that has been largely preserved throughout mammalian evolution. The primary role of MR1 is to present conserved microbial metabolites to highly abundant mucosal-associated invariant T (MAIT) cells. The role of MAIT cells and other MR1-restricted T cells (MR1T) has been recently extended to immunomodulation during cancer. MR1Ts have also been implicated in autoimmune disease. The highly conserved nature of MR1 across the human population is in stark contrast to the MHC molecules recognised by conventional αβ T-cells, therefore MR1Ts may form fertile ground for the development of pan-population T-cell immunotherapeutics for a wide range of important morbidities.",

keywords = "Animals, Antigen Presentation, Autoimmune Diseases/immunology, HLA Antigens/genetics, Histocompatibility Antigens Class I/metabolism, Humans, Immunotherapy, Adoptive/methods, Infections/immunology, Minor Histocompatibility Antigens/metabolism, Mucosal-Associated Invariant T Cells/immunology, Neoplasms/immunology, Receptors, Antigen, T-Cell, alpha-beta/genetics, T-Lymphocytes/immunology",

author = "Crowther, {Michael D} and Sewell, {Andrew K}",

note = "Copyright {\textcopyright} 2020. Published by Elsevier Ltd.",

year = "2021",

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doi = "10.1016/j.coi.2020.12.002",

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AU - Crowther, Michael D

AU - Sewell, Andrew K

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N2 - MR1 is a ubiquitously expressed, monomorphic antigen presenting molecule that has been largely preserved throughout mammalian evolution. The primary role of MR1 is to present conserved microbial metabolites to highly abundant mucosal-associated invariant T (MAIT) cells. The role of MAIT cells and other MR1-restricted T cells (MR1T) has been recently extended to immunomodulation during cancer. MR1Ts have also been implicated in autoimmune disease. The highly conserved nature of MR1 across the human population is in stark contrast to the MHC molecules recognised by conventional αβ T-cells, therefore MR1Ts may form fertile ground for the development of pan-population T-cell immunotherapeutics for a wide range of important morbidities.

AB - MR1 is a ubiquitously expressed, monomorphic antigen presenting molecule that has been largely preserved throughout mammalian evolution. The primary role of MR1 is to present conserved microbial metabolites to highly abundant mucosal-associated invariant T (MAIT) cells. The role of MAIT cells and other MR1-restricted T cells (MR1T) has been recently extended to immunomodulation during cancer. MR1Ts have also been implicated in autoimmune disease. The highly conserved nature of MR1 across the human population is in stark contrast to the MHC molecules recognised by conventional αβ T-cells, therefore MR1Ts may form fertile ground for the development of pan-population T-cell immunotherapeutics for a wide range of important morbidities.

KW - Animals

KW - Antigen Presentation

KW - Autoimmune Diseases/immunology

KW - HLA Antigens/genetics

KW - Histocompatibility Antigens Class I/metabolism

KW - Humans

KW - Immunotherapy, Adoptive/methods

KW - Infections/immunology

KW - Minor Histocompatibility Antigens/metabolism

KW - Mucosal-Associated Invariant T Cells/immunology

KW - Neoplasms/immunology

KW - Receptors, Antigen, T-Cell, alpha-beta/genetics

KW - T-Lymphocytes/immunology

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U2 - 10.1016/j.coi.2020.12.002

DO - 10.1016/j.coi.2020.12.002

M3 - Review

C2 - 33434741

SN - 0952-7915

VL - 69

SP - 10

EP - 17

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease

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Keywords

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