The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

Ehm Astrid Andersson; Marie Neergaard Harder; Kasper Pilgaard; Charlotta Pisinger; Alena Stančáková; Johanna Kuusisto; Niels Grarup; Kristine Færch; Pernille Hasse Busk Poulsen; Daniel Rinse Witte; Torben Jørgensen; Allan Vaag; Markku Laakso; Oluf Borbye Pedersen; Torben Hansen

doi:10.1371/journal.pone.0027096

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

Ehm Astrid Andersson, Marie Neergaard Harder, Kasper Pilgaard, Charlotta Pisinger, Alena Stančáková, Johanna Kuusisto, Niels Grarup, Kristine Færch, Pernille Hasse Busk Poulsen, Daniel Rinse Witte, Torben Jørgensen, Allan Vaag, Markku Laakso, Oluf Borbye Pedersen, Torben Hansen

12 Citations (Scopus)

Abstract

The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1. We aimed to replicate the association with birth weight in the Danish Inter99 study and furthermore to evaluate associations between rs900400 and indices of insulin secretion and insulin sensitivity obtained by oral glucose tolerance tests in adults from the Danish Inter99 study and the Finnish, Metabolic Syndrome in Men (METSIM) sample.

Original language	English
Journal	P L o S One
Volume	6
Issue number	11
Pages (from-to)	e27096
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0027096
Publication status	Published - 2011

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Andersson, E. A., Harder, M. N., Pilgaard, K., Pisinger, C., Stančáková, A., Kuusisto, J., Grarup, N., Færch, K., Poulsen, P. H. B., Witte, D. R., Jørgensen, T., Vaag, A., Laakso, M., Pedersen, O. B., & Hansen, T. (2011). The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge. P L o S One, 6(11), e27096. https://doi.org/10.1371/journal.pone.0027096

Andersson, EA, Harder, MN, Pilgaard, K, Pisinger, C, Stančáková, A, Kuusisto, J, Grarup, N, Færch, K, Poulsen, PHB, Witte, DR, Jørgensen, T , Vaag, A, Laakso, M, Pedersen, OB & Hansen, T 2011, 'The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge', P L o S One, vol. 6, no. 11, pp. e27096. https://doi.org/10.1371/journal.pone.0027096

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AU - Pisinger, Charlotta

AU - Stančáková, Alena

AU - Kuusisto, Johanna

AU - Grarup, Niels

AU - Færch, Kristine

AU - Poulsen, Pernille Hasse Busk

AU - Witte, Daniel Rinse

AU - Jørgensen, Torben

AU - Vaag, Allan

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AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

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The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

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