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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The background and philosophy behind daylight photodynamic therapy

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  2. Photodynamic therapy of necrobiosis lipoidica using methyl aminolevulinate: A retrospective follow-up study

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  3. Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage

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Conventional photodynamic therapy (PDT) is associated with side effects, primarily related to the waiting time between pretreatment with application of photosensitizer and illumination. Pain during illumination is a major issue for the patients and options for effective pain relief are limited. Post-treatment inflammation can often be severe and cause inconvenient down-time for the patients and their employers. To avoid the problems of pain and patients crowding in the clinic we eliminated red light treatment of high PpIX concentration and introduced illumination in daylight which may be performed at home. We also investigated if protoporphyrin IX (PpIX) could be activated continuously during its formation which might reduce pain and inflammation. Continuous activation of PpIX during its formation turned out to minimize pain as single PpIX molecules are activated continuously without accumulation of PpIX in the skin. PpIX molecules are formed in the mitochondria and the photodynamic effect only takes place in the mitochondria when continuously activated. This results primarily in apoptosis with little inflammation. Continuous activation of PpIX can be obtained by performing photodynamic therapy in daylight, as well as with daylight-emitting light sources of appropriate wavelengths. Use of daylight prevents the patients from crowding in the clinic. Daylight-PDT completely fulfils the purpose of minimizing pain and inflammation, as well as limiting the strain on the clinic treating the patients.

Original languageEnglish
JournalGiornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
Volume153
Issue number6
Pages (from-to)776-782
Number of pages7
ISSN0392-0488
DOIs
Publication statusPublished - Dec 2018

ID: 56141364