Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Association between Use of ICS and Psychiatric Symptoms in Patients with COPD—A Nationwide Cohort Study of 49,500 Patients

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The Importance of Lipoprotein Lipase Regulation in Atherosclerosis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Risk of Chronic Obstructive Pulmonary Disease Exacerbation in Patients Who Use Methotrexate-A Nationwide Study of 58,580 Outpatients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Efficacy and Mode of Action of Mesenchymal Stem Cells in Non-Ischemic Dilated Cardiomyopathy: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  4. The Phenotypic Spectrum of PRRT2-Associated Paroxysmal Neurologic Disorders in Childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Early diastolic strain rate in relation to long term prognosis following isolated coronary artery bypass grafting

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Global longitudinal strain predicts atrial fibrillation in individuals without hypertension: A Community-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prognostic value of right ventricular echocardiographic measures in patients with heart failure with reduced ejection fraction

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Serum Potassium and Mortality in High-Risk Patients: SPRINT

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Psychiatric side effects are well known from treatment with systemic corticosteroids. It is, however, unclear whether inhaled corticosteroids (ICS) have psychiatric side effects in patients with COPD. We conducted a nationwide cohort study in all Danish COPD outpatients who had respiratory medicine specialist-verified COPD, age ≥40 years, and no previous cancer. Prescription fillings of antidepressants and risk of admissions to psychiatric hospitals with either depression, anxiety or bipolar disorder were assessed by Cox proportional hazards models. We observed a dose-dependent increase in the risk of antidepressant-use with ICS cumulated dose (HR 1.05, 95% CI 1.03-1.07, p = 0.0472 with low ICS exposure, HR 1.10, 95% CI 1.08-1.12, p < 0.0001 with medium exposure, HR 1.15, 95% CI 1.11-1.15, p < 0.0001 with high exposure) as compared to no ICS exposure. We found a discrete increased risk of admission to psychiatric hospitals in the medium and high dose group (HR 1.00, 95% CI 0.98-1.03, p = 0.77 with low ICS exposure, HR 1.07, 95% CI 1.05-1.10, p < 0.0001 with medium exposure, HR 1.13, 95% CI 1.10-1.15, p < 0.0001 with high exposure). The association persisted when stratifying for prior antidepressant use. Thus, exposure to ICS was associated with a small to moderate increase in antidepressant-use and psychiatric admissions.

Original languageEnglish
Article number1492
JournalBiomedicines
Volume9
Issue number10
ISSN2227-9059
DOIs
Publication statusPublished - 18 Oct 2021

    Research areas

  • Anxiety, Bipolar disorder, COPD, Depression, ICS, Obstructive lung disease

ID: 68452727