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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The association between the Pro12Ala polymorphism in the PPARg gene and: The Skaraborg Project

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  2. Body fat and fat-free mass and all-cause mortality

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  3. Hip circumference and cardiovascular morbidity and mortality in men and women

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  4. Leptin levels are associated with fat oxidation and dietary-induced weight loss in obesity

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  5. Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy.

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The interaction between the Pro12Ala polymorphism in peroxisome-proliferator-activator receptor gamma PPARg -2 and physical activity in the association with obesity (BMI ≥30 kg m-2) was explored in 901 women and 903 men between 30 and 75 years participating in a population survey of cardiovascular disease risk factors in Vara, Sweden, (participation rate 81%). Questionnaires and interviews covered physical activity at leisure time (LTPA), smoking habits and socio-economic background, and anthropometric measures were ascertained. Obesity was found in 26% of the women and 20% of the men. The proportion carrying the Pro12Ala variant allele was 24% in both sexes. In women ≥50 years Ala carriage was associated with obesity (OR: 1.79, CI: 1.05-3.07). This association was stronger in women with a low LTPA (OR: 2.01, CI: 1.10-3.67), but was not present in those with a high level of LTPA (OR: 1.06, CI: 0.19-5.91). This association was not seen in men or in women <50 years of age. In conclusion the Ala allele of the Pro12Ala polymorphism was associated with obesity in women above 50 years, but this risk was prevented already by a moderate level of LTPA. These findings support the emphasis on physical activity in the prevention of obesity.
Original languageEnglish
JournalObesity Research
Publication statusSubmitted - 2006

    Research areas

  • Physical activity, PPARG, Obesity, Genetics

ID: 32514068