Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The association between pre-operative sepsis and 30-day mortality in hip fracture patients-A cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Delirium assessment in neuro-critically ill patients: A validation study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Rebound pain following peripheral nerve block anaesthesia in acute ankle fracture surgery: An exploratory pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Association between perioperative hyperoxia and cerebrovascular complications after laparotomy-A post-hoc follow-up study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Bleeding and thrombosis in intensive care patients with thrombocytopenia-Protocol for a topical systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  1. Association between perioperative hyperoxia and cerebrovascular complications after laparotomy-A post-hoc follow-up study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Oxygenation targets in acutely ill patients: still a matter of debate

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Post-operative sepsis considerably increases mortality, but the extent of pre-operative sepsis in hip fracture patients and its consequences are sparsely elucidated. The aim of this study was to assess the association between pre-operative sepsis and 30-day mortality after hip fracture surgery.

METHODS: We conducted a retrospective analysis of data collected among 1894 patients who underwent hip fracture surgery in the Capital Region of Denmark in 2014 (NCT03201679). Data on vital signs, cultures and laboratory data were obtained. Sepsis was defined as a positive culture of any kind and presence of systemic inflammatory response syndrome within 24 hours and was assessed within 72 hours before surgery and 30 days post-operatively. Primary outcome was 30-day mortality. Secondary outcomes included length of hospital stay and admission to intensive care unit.

RESULTS: A total of 144 (7.6%) of the hip fracture patients met the criteria for pre-operative sepsis. The 30-day mortality was 13.9% in patients with pre-operative sepsis as compared to 9.0% in those without (OR 1.69, 95% CI [1.00; 2.85], P = .08). Patients with pre-operative sepsis had longer hospital stays (median 10 days vs 9 days, mean difference 2.1 [SD 9.4] days, P = .03), and higher frequency of ICU admission (11.1% vs 2.7%, OR 4.15, 95% CI [2.19; 7.87], P < .0001).

CONCLUSION: Pre-operative sepsis in hip fracture patients was associated with an increased length of hospital stay and tended to increase mortality. Pre-operative sepsis in hip fracture patients merits more intensive surveillance and increased attention to timely treatment.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume62
Issue number9
Pages (from-to)1209-1214
ISSN0001-5172
DOIs
Publication statusPublished - 1 Sep 2018

ID: 54932078