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The association between neonatal vitamin D status and risk of schizophrenia

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  • Darryl W Eyles
  • Maciej Trzaskowski
  • Anna A E Vinkhuyzen
  • Manuel Mattheisen
  • Sandra Meier
  • Helen Gooch
  • Victor Anggono
  • Xiaoying Cui
  • Men Chee Tan
  • Thomas H J Burne
  • Se Eun Jang
  • David Kvaskoff
  • David M Hougaard
  • Bent Nørgaard-Pedersen
  • Arieh Cohen
  • Esben Agerbo
  • Carsten B Pedersen
  • Anders D Børglum
  • Ole Mors
  • Pankaj Sah
  • Naomi R Wray
  • Preben B Mortensen
  • John J McGrath
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Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Incidence rate ratios (IRR) were calculated when examined for quintiles of 25OHD concentration. In addition, we examined statistical models that combined 25OHD concentration and the schizophrenia polygenic risk score (PRS) in a sample that combined the new sample with a previous study (total n = 3464; samples assayed and genotyped between 2008-2013). Compared to the reference (fourth) quintile, those in the lowest quintile (<20.4 nmol/L) had a significantly increased risk of schizophrenia (IRR = 1.44, 95%CI: 1.12-1.85). None of the other quintile comparisons were significantly different. There was no significant interaction between 25OHD and the PRS. Neonatal vitamin D deficiency was associated with an increased risk for schizophrenia in later life. These findings could have important public health implications related to the primary prevention of schizophrenia.

Original languageEnglish
Article number17692
JournalScientific Reports
Volume8
Issue number1
Number of pages8
ISSN2045-2322
DOIs
Publication statusPublished - 6 Dec 2018

ID: 56707902