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The association between migrant status and transition in an ultra-high risk for psychosis population

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Harvard

O'Donoghue, B, Geros, H, Sizer, H, Addington, J, Amminger, GP, Beaden, CE, Cadenhead, KS, Cannon, TD, Cornblatt, BA, Berger, GE, Chen, EYH, de Haan, L, Hartmann, JA, Hickie, IB, Ising, HK, Lavoie, S, Lin, A, Markulev, C, Mathalon, DH, McGlashan, TH, Mifsud, NG, Mossaheb, N, Nieman, DH, Nordentoft, M, Perkins, DO, Riecher-Rössler, A, Schäfer, MR, Schlögelhofer, M, Seidman, LJ, Smesny, S, Thompson, A, Tsuang, MT, van der Gaag, M, Verma, S, Walker, EF, Wood, SJ, Woods, SW, Yuen, HP, Yung, AR, McGorry, PD & Nelson, B 2021, 'The association between migrant status and transition in an ultra-high risk for psychosis population', Social Psychiatry and Psychiatric Epidemiology, vol. 56, no. 6, pp. 943-952. https://doi.org/10.1007/s00127-020-02012-6

APA

O'Donoghue, B., Geros, H., Sizer, H., Addington, J., Amminger, G. P., Beaden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Berger, G. E., Chen, E. Y. H., de Haan, L., Hartmann, J. A., Hickie, I. B., Ising, H. K., Lavoie, S., Lin, A., Markulev, C., Mathalon, D. H., ... Nelson, B. (2021). The association between migrant status and transition in an ultra-high risk for psychosis population. Social Psychiatry and Psychiatric Epidemiology, 56(6), 943-952. https://doi.org/10.1007/s00127-020-02012-6

CBE

O'Donoghue B, Geros H, Sizer H, Addington J, Amminger GP, Beaden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Berger GE, Chen EYH, de Haan L, Hartmann JA, Hickie IB, Ising HK, Lavoie S, Lin A, Markulev C, Mathalon DH, McGlashan TH, Mifsud NG, Mossaheb N, Nieman DH, Nordentoft M, Perkins DO, Riecher-Rössler A, Schäfer MR, Schlögelhofer M, Seidman LJ, Smesny S, Thompson A, Tsuang MT, van der Gaag M, Verma S, Walker EF, Wood SJ, Woods SW, Yuen HP, Yung AR, McGorry PD, Nelson B. 2021. The association between migrant status and transition in an ultra-high risk for psychosis population. Social Psychiatry and Psychiatric Epidemiology. 56(6):943-952. https://doi.org/10.1007/s00127-020-02012-6

MLA

Vancouver

Author

O'Donoghue, Brian ; Geros, Hellen ; Sizer, Holly ; Addington, Jean ; Amminger, G Paul ; Beaden, Carrie E ; Cadenhead, Kristin S ; Cannon, Tyrone D ; Cornblatt, Barbara A ; Berger, Gregor Emanuel ; Chen, Eric Y H ; de Haan, Lieuwe ; Hartmann, Jessica A ; Hickie, Ian B ; Ising, Helga K ; Lavoie, Suzie ; Lin, Ashleigh ; Markulev, Connie ; Mathalon, Daniel H ; McGlashan, Thomas H ; Mifsud, Nathan G ; Mossaheb, Nilufar ; Nieman, Dorien H ; Nordentoft, Merete ; Perkins, Diana O ; Riecher-Rössler, Anita ; Schäfer, Miriam R ; Schlögelhofer, Monika ; Seidman, Larry J ; Smesny, Stephan ; Thompson, Andrew ; Tsuang, Ming T ; van der Gaag, Mark ; Verma, Swapna ; Walker, Elaine F ; Wood, Stephen J ; Woods, Scott W ; Yuen, Hok Pan ; Yung, Alison Ruth ; McGorry, Patrick D ; Nelson, Barnaby. / The association between migrant status and transition in an ultra-high risk for psychosis population. In: Social Psychiatry and Psychiatric Epidemiology. 2021 ; Vol. 56, No. 6. pp. 943-952.

Bibtex

@article{5bc3668fab794138a825531fe9a94c28,
title = "The association between migrant status and transition in an ultra-high risk for psychosis population",
abstract = "PURPOSE: Migrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder.METHODS: Hazard ratios for the risk of transition were calculated from five large UHR cohorts (n = 2166) and were used to conduct a meta-analysis using the generic inverse-variance method using a random-effects model.RESULTS: 2166 UHR young people, with a mean age of 19.1 years (SD ± 4.5) were included, of whom 221 (10.7%) were first-generation migrants. A total of 357 young people transitioned to psychosis over a median follow-up time of 417 days (I.Q.R.147-756 days), representing 17.0% of the cohort. The risk of transition to a full-threshold disorder was not increased for first-generation migrants, (HR = 1.08, 95% CI 0.62-1.89); however, there was a high level of heterogeneity between studies The hazard ratio for second-generation migrants to transition to a full-threshold psychotic disorder compared to the remainder of the native-born population was 1.03 (95% CI 0.70-1.51).CONCLUSIONS: This meta-analysis did not find a statistically significant association between migrant status and an increased risk for transition to a full-threshold psychotic disorder; however, several methodological issues could explain this finding. Further research should focus on examining the risk of specific migrant groups and also ensuring that migrant populations are adequately represented within UHR clinics.",
keywords = "Migrants, Psychotic disorders, Ultra-high risk for psychosis",
author = "Brian O'Donoghue and Hellen Geros and Holly Sizer and Jean Addington and Amminger, {G Paul} and Beaden, {Carrie E} and Cadenhead, {Kristin S} and Cannon, {Tyrone D} and Cornblatt, {Barbara A} and Berger, {Gregor Emanuel} and Chen, {Eric Y H} and {de Haan}, Lieuwe and Hartmann, {Jessica A} and Hickie, {Ian B} and Ising, {Helga K} and Suzie Lavoie and Ashleigh Lin and Connie Markulev and Mathalon, {Daniel H} and McGlashan, {Thomas H} and Mifsud, {Nathan G} and Nilufar Mossaheb and Nieman, {Dorien H} and Merete Nordentoft and Perkins, {Diana O} and Anita Riecher-R{\"o}ssler and Sch{\"a}fer, {Miriam R} and Monika Schl{\"o}gelhofer and Seidman, {Larry J} and Stephan Smesny and Andrew Thompson and Tsuang, {Ming T} and {van der Gaag}, Mark and Swapna Verma and Walker, {Elaine F} and Wood, {Stephen J} and Woods, {Scott W} and Yuen, {Hok Pan} and Yung, {Alison Ruth} and McGorry, {Patrick D} and Barnaby Nelson",
year = "2021",
month = jun,
doi = "10.1007/s00127-020-02012-6",
language = "English",
volume = "56",
pages = "943--952",
journal = "Social Psychiatry",
issn = "0933-7954",
publisher = "Dr. Dietrich/Steinkopff Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - The association between migrant status and transition in an ultra-high risk for psychosis population

AU - O'Donoghue, Brian

AU - Geros, Hellen

AU - Sizer, Holly

AU - Addington, Jean

AU - Amminger, G Paul

AU - Beaden, Carrie E

AU - Cadenhead, Kristin S

AU - Cannon, Tyrone D

AU - Cornblatt, Barbara A

AU - Berger, Gregor Emanuel

AU - Chen, Eric Y H

AU - de Haan, Lieuwe

AU - Hartmann, Jessica A

AU - Hickie, Ian B

AU - Ising, Helga K

AU - Lavoie, Suzie

AU - Lin, Ashleigh

AU - Markulev, Connie

AU - Mathalon, Daniel H

AU - McGlashan, Thomas H

AU - Mifsud, Nathan G

AU - Mossaheb, Nilufar

AU - Nieman, Dorien H

AU - Nordentoft, Merete

AU - Perkins, Diana O

AU - Riecher-Rössler, Anita

AU - Schäfer, Miriam R

AU - Schlögelhofer, Monika

AU - Seidman, Larry J

AU - Smesny, Stephan

AU - Thompson, Andrew

AU - Tsuang, Ming T

AU - van der Gaag, Mark

AU - Verma, Swapna

AU - Walker, Elaine F

AU - Wood, Stephen J

AU - Woods, Scott W

AU - Yuen, Hok Pan

AU - Yung, Alison Ruth

AU - McGorry, Patrick D

AU - Nelson, Barnaby

PY - 2021/6

Y1 - 2021/6

N2 - PURPOSE: Migrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder.METHODS: Hazard ratios for the risk of transition were calculated from five large UHR cohorts (n = 2166) and were used to conduct a meta-analysis using the generic inverse-variance method using a random-effects model.RESULTS: 2166 UHR young people, with a mean age of 19.1 years (SD ± 4.5) were included, of whom 221 (10.7%) were first-generation migrants. A total of 357 young people transitioned to psychosis over a median follow-up time of 417 days (I.Q.R.147-756 days), representing 17.0% of the cohort. The risk of transition to a full-threshold disorder was not increased for first-generation migrants, (HR = 1.08, 95% CI 0.62-1.89); however, there was a high level of heterogeneity between studies The hazard ratio for second-generation migrants to transition to a full-threshold psychotic disorder compared to the remainder of the native-born population was 1.03 (95% CI 0.70-1.51).CONCLUSIONS: This meta-analysis did not find a statistically significant association between migrant status and an increased risk for transition to a full-threshold psychotic disorder; however, several methodological issues could explain this finding. Further research should focus on examining the risk of specific migrant groups and also ensuring that migrant populations are adequately represented within UHR clinics.

AB - PURPOSE: Migrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder.METHODS: Hazard ratios for the risk of transition were calculated from five large UHR cohorts (n = 2166) and were used to conduct a meta-analysis using the generic inverse-variance method using a random-effects model.RESULTS: 2166 UHR young people, with a mean age of 19.1 years (SD ± 4.5) were included, of whom 221 (10.7%) were first-generation migrants. A total of 357 young people transitioned to psychosis over a median follow-up time of 417 days (I.Q.R.147-756 days), representing 17.0% of the cohort. The risk of transition to a full-threshold disorder was not increased for first-generation migrants, (HR = 1.08, 95% CI 0.62-1.89); however, there was a high level of heterogeneity between studies The hazard ratio for second-generation migrants to transition to a full-threshold psychotic disorder compared to the remainder of the native-born population was 1.03 (95% CI 0.70-1.51).CONCLUSIONS: This meta-analysis did not find a statistically significant association between migrant status and an increased risk for transition to a full-threshold psychotic disorder; however, several methodological issues could explain this finding. Further research should focus on examining the risk of specific migrant groups and also ensuring that migrant populations are adequately represented within UHR clinics.

KW - Migrants

KW - Psychotic disorders

KW - Ultra-high risk for psychosis

UR - http://www.scopus.com/inward/record.url?scp=85099180219&partnerID=8YFLogxK

U2 - 10.1007/s00127-020-02012-6

DO - 10.1007/s00127-020-02012-6

M3 - Journal article

C2 - 33399885

VL - 56

SP - 943

EP - 952

JO - Social Psychiatry

JF - Social Psychiatry

SN - 0933-7954

IS - 6

ER -

ID: 61732772