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The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

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  1. Progressive DNA and RNA damage from oxidation after aneurysmal subarachnoid haemorrhage in humans

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  2. Urinary markers of nucleic acid oxidation in Danish overweight/obese children and youths

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  3. Assays for urinary biomarkers of oxidatively damaged nucleic acids

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  4. Body iron is a contributor to oxidative damage of DNA

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  1. Polygenic predisposition to breast cancer and the risk of coronary artery disease

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  2. Clinical, Physiologic, and Behavioral Evaluation of Permanently Catheterized NMRI Mice

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  3. Discrepancies Between the Medication List in Electronic Prescribing Systems and Patients' Actual Use of Medicines

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  4. A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder

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This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.
Original languageEnglish
JournalFree Radical Research
Volume45
Issue number4
Pages (from-to)409-16
Number of pages8
ISSN1071-5762
DOIs
Publication statusPublished - 1 Apr 2011

ID: 32313054