The Association between Genetic Variations of CHI3L1, Levels of the Encoded Glycoprotein YKL-40 and the Lipid Profile in a Danish Population

Stine Brinkløv Thomsen, Camilla Noelle Rathcke, Tea Skaaby, Allan Linneberg, Henrik Vestergaard

    19 Citations (Scopus)

    Abstract

    The inflammatory biomarker YKL-40 seems to play a role in atherosclerosis and is elevated in patients with obesity, cardiovascular disease and type 2 diabetes. Single nucleotide polymorphisms (SNPs) of the YKL-40 encoding gene, CHI3L1, are associated with inter-individual YKL-40 levels. One study has described an association between a promoter polymorphism of CHI3L1 and levels of low density lipoprotein. The objective of this study was to evaluate the influence of YKL-40 on lipid parameters by determining the association between polymorphisms of CHI3L1, serum YKL-40 and levels of the differentiated lipid profile in a Danish general population.
    Original languageEnglish
    JournalP L o S One
    Volume7
    Issue number10
    Pages (from-to)e47094
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2012

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