THE ASSOCIATION BETWEEN CUTICULAR DRUSEN AND KIDNEY FUNCTION: A Population-Based Case-Control Study

Tracy B Høeg; Ronald Klein; Birgitte Moldow; Morten La Cour; Kristian Klemp; Ditte Erngaard; Helena Hesgaard; Christina Ellervik

doi:10.1097/IAE.0000000000000808

THE ASSOCIATION BETWEEN CUTICULAR DRUSEN AND KIDNEY FUNCTION: A Population-Based Case-Control Study

Tracy B Høeg, Ronald Klein, Birgitte Moldow, Morten La Cour, Kristian Klemp, Ditte Erngaard, Helena Hesgaard, Christina Ellervik

Department of Ophthalmology

Abstract

PURPOSE: To determine the association between cuticular drusen (CD) and kidney function.

DESIGN: observational case-control study.

METHODS:

SETTING: Population-based. Patients or Study Population: 53 participants with (CD) and 53 age- and sex-matched controls, selected from the Danish Rural Eye Study. Cuticular drusen participants were diagnosed using fluorescein angiography and controls were excluded if the patients were suspected of having CD on fundus photography or did not have an available estimated glomerular filtration rate.

MAIN OUTCOME MEASURES: creatinine and estimated glomerular filtration rate.

RESULTS: The mean estimated glomerular filtration rate of those with CD was 73.3 mL·min·1.73 m (95% confidence interval [CI]: 70.0-76.6) and 73.4 mL·minute·1.73 m (95% CI: 69.5-77.3) in controls. The difference was not significant (P: 0.970). The mean creatinine among those with CD was 72.8 μmol/L (69.3-76.4) and 73.5 μmol/L (95% CI: 69.3-77.6) among controls. The difference was not significant (P = 0.820).

CONCLUSION: The authors did not find an association between a (CD) diagnosis and decreased kidney function at a population level.

Original language	English
Journal	Retina (Philadelphia, Pa.)
Volume	36
Issue number	5
Pages (from-to)	896-900
Number of pages	5
ISSN	0275-004X
DOIs	https://doi.org/10.1097/IAE.0000000000000808
Publication status	Published - May 2016

Keywords

Aged
Aged, 80 and over
Bruch Membrane
Case-Control Studies
Creatinine
Eye Diseases, Hereditary
Female
Fluorescein Angiography
Glomerular Filtration Rate
Humans
Kidney
Male
Middle Aged
Retinal Drusen
Journal Article

Access to Document

10.1097/IAE.0000000000000808

Cite this

@article{be6b744bb4454771bf621ef61a2cd63c,

title = "THE ASSOCIATION BETWEEN CUTICULAR DRUSEN AND KIDNEY FUNCTION: A Population-Based Case-Control Study",

abstract = "PURPOSE: To determine the association between cuticular drusen (CD) and kidney function.DESIGN: observational case-control study.METHODS: SETTING: Population-based. Patients or Study Population: 53 participants with (CD) and 53 age- and sex-matched controls, selected from the Danish Rural Eye Study. Cuticular drusen participants were diagnosed using fluorescein angiography and controls were excluded if the patients were suspected of having CD on fundus photography or did not have an available estimated glomerular filtration rate.MAIN OUTCOME MEASURES: creatinine and estimated glomerular filtration rate.RESULTS: The mean estimated glomerular filtration rate of those with CD was 73.3 mL·min·1.73 m (95\% confidence interval [CI]: 70.0-76.6) and 73.4 mL·minute·1.73 m (95\% CI: 69.5-77.3) in controls. The difference was not significant (P: 0.970). The mean creatinine among those with CD was 72.8 μmol/L (69.3-76.4) and 73.5 μmol/L (95\% CI: 69.3-77.6) among controls. The difference was not significant (P = 0.820).CONCLUSION: The authors did not find an association between a (CD) diagnosis and decreased kidney function at a population level.",

keywords = "Aged, Aged, 80 and over, Bruch Membrane, Case-Control Studies, Creatinine, Eye Diseases, Hereditary, Female, Fluorescein Angiography, Glomerular Filtration Rate, Humans, Kidney, Male, Middle Aged, Retinal Drusen, Journal Article",

author = "H{\o}eg, \{Tracy B\} and Ronald Klein and Birgitte Moldow and \{La Cour\}, Morten and Kristian Klemp and Ditte Erngaard and Helena Hesgaard and Christina Ellervik",

year = "2016",

month = may,

doi = "10.1097/IAE.0000000000000808",

language = "English",

volume = "36",

pages = "896--900",

journal = "Retina (Philadelphia, Pa.)",

issn = "0275-004X",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - THE ASSOCIATION BETWEEN CUTICULAR DRUSEN AND KIDNEY FUNCTION

T2 - A Population-Based Case-Control Study

AU - Høeg, Tracy B

AU - Klein, Ronald

AU - Moldow, Birgitte

AU - La Cour, Morten

AU - Klemp, Kristian

AU - Erngaard, Ditte

AU - Hesgaard, Helena

AU - Ellervik, Christina

PY - 2016/5

Y1 - 2016/5

N2 - PURPOSE: To determine the association between cuticular drusen (CD) and kidney function.DESIGN: observational case-control study.METHODS: SETTING: Population-based. Patients or Study Population: 53 participants with (CD) and 53 age- and sex-matched controls, selected from the Danish Rural Eye Study. Cuticular drusen participants were diagnosed using fluorescein angiography and controls were excluded if the patients were suspected of having CD on fundus photography or did not have an available estimated glomerular filtration rate.MAIN OUTCOME MEASURES: creatinine and estimated glomerular filtration rate.RESULTS: The mean estimated glomerular filtration rate of those with CD was 73.3 mL·min·1.73 m (95% confidence interval [CI]: 70.0-76.6) and 73.4 mL·minute·1.73 m (95% CI: 69.5-77.3) in controls. The difference was not significant (P: 0.970). The mean creatinine among those with CD was 72.8 μmol/L (69.3-76.4) and 73.5 μmol/L (95% CI: 69.3-77.6) among controls. The difference was not significant (P = 0.820).CONCLUSION: The authors did not find an association between a (CD) diagnosis and decreased kidney function at a population level.

AB - PURPOSE: To determine the association between cuticular drusen (CD) and kidney function.DESIGN: observational case-control study.METHODS: SETTING: Population-based. Patients or Study Population: 53 participants with (CD) and 53 age- and sex-matched controls, selected from the Danish Rural Eye Study. Cuticular drusen participants were diagnosed using fluorescein angiography and controls were excluded if the patients were suspected of having CD on fundus photography or did not have an available estimated glomerular filtration rate.MAIN OUTCOME MEASURES: creatinine and estimated glomerular filtration rate.RESULTS: The mean estimated glomerular filtration rate of those with CD was 73.3 mL·min·1.73 m (95% confidence interval [CI]: 70.0-76.6) and 73.4 mL·minute·1.73 m (95% CI: 69.5-77.3) in controls. The difference was not significant (P: 0.970). The mean creatinine among those with CD was 72.8 μmol/L (69.3-76.4) and 73.5 μmol/L (95% CI: 69.3-77.6) among controls. The difference was not significant (P = 0.820).CONCLUSION: The authors did not find an association between a (CD) diagnosis and decreased kidney function at a population level.

KW - Aged

KW - Aged, 80 and over

KW - Bruch Membrane

KW - Case-Control Studies

KW - Creatinine

KW - Eye Diseases, Hereditary

KW - Female

KW - Fluorescein Angiography

KW - Glomerular Filtration Rate

KW - Humans

KW - Kidney

KW - Male

KW - Middle Aged

KW - Retinal Drusen

KW - Journal Article

UR - https://www.scopus.com/pages/publications/84966480778

U2 - 10.1097/IAE.0000000000000808

DO - 10.1097/IAE.0000000000000808

M3 - Journal article

C2 - 27115854

SN - 0275-004X

VL - 36

SP - 896

EP - 900

JO - Retina (Philadelphia, Pa.)

JF - Retina (Philadelphia, Pa.)

IS - 5

ER -

THE ASSOCIATION BETWEEN CUTICULAR DRUSEN AND KIDNEY FUNCTION: A Population-Based Case-Control Study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this