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The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

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  1. ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

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  2. Single mRNP Analysis Reveals that Small Cytoplasmic mRNP Granules Represent mRNA Singletons

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  3. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

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  4. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

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  5. Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

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  1. Reduced apolipoprotein M and adverse outcomes across the spectrum of human heart failure

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  2. Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature

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  3. Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

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  4. Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

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Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

Original languageEnglish
JournalCell Reports
Volume22
Issue number1
Pages (from-to)175-188
Number of pages14
DOIs
Publication statusPublished - 2 Jan 2018

ID: 55063964