The Angioarchitecture of the Optic Nerve Head in Patients with Optic Disc Drusen

Julie Vahlgren; Lasse Malmqvist; Lea Lybæk Rueløkke; Isabelle Karlesand; Anne Sofie Wessel Lindberg; Steffen Hamann

doi:10.1080/01658107.2019.1613666

The Angioarchitecture of the Optic Nerve Head in Patients with Optic Disc Drusen

Julie Vahlgren, Lasse Malmqvist, Lea Lybæk Rueløkke, Isabelle Karlesand, Anne Sofie Wessel Lindberg, Steffen Hamann^*

^*Corresponding author for this work

Department of Ophthalmology

6 Citations (Scopus)

Abstract

The aim was to analyse the optic disc angioarchitecture in optic disc drusen (ODD) patients using computer-based fundus analysis in a case–control study. Compared with controls the ODD group had a significantly more centralised central retinal artery (CRA) emergence (p < 0.001) and primary CRA branching (p = 0.008), a higher number of CRA bifurcations (p = 0.02), a larger vertical optic disc diameter (p = 0.02) and a smaller cup/disc ratio (p < 0.001). The CRA emergence was largely within the nasal zone for both groups. The distinctive angioarchitecture of the optic disc in ODD patients can play a role in understanding the pathogenic cause of ODD.

Original language	English
Journal	Neuro-Ophthalmology
Volume	44
Issue number	1
Pages (from-to)	5-10
Number of pages	6
ISSN	0165-8107
DOIs	https://doi.org/10.1080/01658107.2019.1613666
Publication status	Published - Feb 2020

Keywords

Optic disc drusen
optic nerve head angioarchitecture
optic nerve head drusen
optic nerve head microvasculature

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10.1080/01658107.2019.1613666

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title = "The Angioarchitecture of the Optic Nerve Head in Patients with Optic Disc Drusen",

abstract = "The aim was to analyse the optic disc angioarchitecture in optic disc drusen (ODD) patients using computer-based fundus analysis in a case–control study. Compared with controls the ODD group had a significantly more centralised central retinal artery (CRA) emergence (p < 0.001) and primary CRA branching (p = 0.008), a higher number of CRA bifurcations (p = 0.02), a larger vertical optic disc diameter (p = 0.02) and a smaller cup/disc ratio (p < 0.001). The CRA emergence was largely within the nasal zone for both groups. The distinctive angioarchitecture of the optic disc in ODD patients can play a role in understanding the pathogenic cause of ODD.",

keywords = "Optic disc drusen, optic nerve head angioarchitecture, optic nerve head drusen, optic nerve head microvasculature",

author = "Julie Vahlgren and Lasse Malmqvist and Ruel{\o}kke, \{Lea Lyb{\ae}k\} and Isabelle Karlesand and Lindberg, \{Anne Sofie Wessel\} and Steffen Hamann",

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T1 - The Angioarchitecture of the Optic Nerve Head in Patients with Optic Disc Drusen

AU - Vahlgren, Julie

AU - Malmqvist, Lasse

AU - Rueløkke, Lea Lybæk

AU - Karlesand, Isabelle

AU - Lindberg, Anne Sofie Wessel

AU - Hamann, Steffen

PY - 2020/2

Y1 - 2020/2

N2 - The aim was to analyse the optic disc angioarchitecture in optic disc drusen (ODD) patients using computer-based fundus analysis in a case–control study. Compared with controls the ODD group had a significantly more centralised central retinal artery (CRA) emergence (p < 0.001) and primary CRA branching (p = 0.008), a higher number of CRA bifurcations (p = 0.02), a larger vertical optic disc diameter (p = 0.02) and a smaller cup/disc ratio (p < 0.001). The CRA emergence was largely within the nasal zone for both groups. The distinctive angioarchitecture of the optic disc in ODD patients can play a role in understanding the pathogenic cause of ODD.

AB - The aim was to analyse the optic disc angioarchitecture in optic disc drusen (ODD) patients using computer-based fundus analysis in a case–control study. Compared with controls the ODD group had a significantly more centralised central retinal artery (CRA) emergence (p < 0.001) and primary CRA branching (p = 0.008), a higher number of CRA bifurcations (p = 0.02), a larger vertical optic disc diameter (p = 0.02) and a smaller cup/disc ratio (p < 0.001). The CRA emergence was largely within the nasal zone for both groups. The distinctive angioarchitecture of the optic disc in ODD patients can play a role in understanding the pathogenic cause of ODD.

KW - Optic disc drusen

KW - optic nerve head angioarchitecture

KW - optic nerve head drusen

KW - optic nerve head microvasculature

UR - https://www.scopus.com/pages/publications/85079216160

U2 - 10.1080/01658107.2019.1613666

DO - 10.1080/01658107.2019.1613666

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EP - 10

JO - Neuro-Ophthalmology

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ER -

The Angioarchitecture of the Optic Nerve Head in Patients with Optic Disc Drusen

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Keywords

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