TY - JOUR
T1 - The Added Value of Cerebrospinal Fluid Neurofilament Light Chain to Existing Diagnostic Methods and Biomarkers in a Mixed Memory Clinic Cohort of Consecutive Patients
AU - Gleerup, Helena Sophia
AU - Simonsen, Anja Hviid
AU - Høgh, Peter
N1 - © 2022 – The authors. Published by IOS Press.
PY - 2022
Y1 - 2022
N2 - The added value of neurofilament light chain (NfL) to the existing diagnostic methods is unknown, although a plethora of studies have shown increased levels in cerebrospinal fluid (CSF) and blood in many neurodegenerative and neurological disorders. The added value of CSF NfL was determined in a mixed memory clinic cohort of consecutive patients for 136 patients with Alzheimer's disease (AD) (n = 69), mild cognitive impairment (n = 24), non-AD (n = 34), and also healthy controls (n = 9). This study found no increase in the diagnostic accuracy of the etiological diagnoses but knowing the CSF NfL value led to increased diagnostic certainty for the specialist in neurology.
AB - The added value of neurofilament light chain (NfL) to the existing diagnostic methods is unknown, although a plethora of studies have shown increased levels in cerebrospinal fluid (CSF) and blood in many neurodegenerative and neurological disorders. The added value of CSF NfL was determined in a mixed memory clinic cohort of consecutive patients for 136 patients with Alzheimer's disease (AD) (n = 69), mild cognitive impairment (n = 24), non-AD (n = 34), and also healthy controls (n = 9). This study found no increase in the diagnostic accuracy of the etiological diagnoses but knowing the CSF NfL value led to increased diagnostic certainty for the specialist in neurology.
UR - http://www.scopus.com/inward/record.url?scp=85127777557&partnerID=8YFLogxK
U2 - 10.3233/ADR-210047
DO - 10.3233/ADR-210047
M3 - Journal article
C2 - 35530115
SN - 2542-4823
VL - 6
SP - 121
EP - 127
JO - Journal of Alzheimer's disease reports
JF - Journal of Alzheimer's disease reports
IS - 1
ER -