The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis: relation to liver dysfunction

S Møller, A Juul, U Becker, J H Henriksen

22 Citations (Scopus)

Abstract

In the circulation, insulin-like growth factor-I (IGF-I) is bound in a trimeric complex of 150 kDa with IGF binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS). Whereas circulating IGF-I and IGFBP-3 are reported to be low in patients with chronic liver failure, the level of ALS has not been described in relation to hepatic dysfunction. The aim of the present study was therefore to measure circulating and hepatic venous concentrations of ALS in relation to hepatic function and the IGF axis.
Original languageEnglish
JournalJournal of Hepatology
Volume32
Issue number3
Pages (from-to)441-6
Number of pages6
ISSN0168-8278
Publication statusPublished - 2000

Keywords

  • Adult
  • Aged
  • Carrier Proteins
  • Female
  • Glycoproteins
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor I
  • Liver
  • Liver Cirrhosis
  • Male
  • Middle Aged
  • Reference Values

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