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The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation

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  • Gerald J Berry
  • Margaret M Burke
  • Claus Andersen
  • Patrick Bruneval
  • Marny Fedrigo
  • Michael C Fishbein
  • Martin Goddard
  • Elizabeth H Hammond
  • Ornella Leone
  • Charles Marboe
  • Dylan Miller
  • Desley Neil
  • Doris Rassl
  • Monica P Revelo
  • Alexandra Rice
  • E Rene Rodriguez
  • Susan Stewart
  • Carmela D Tan
  • Gayle L Winters
  • Lori West
  • Mandeep R Mehra
  • Annalisa Angelini
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During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers.
Original languageEnglish
JournalThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Volume32
Issue number12
Pages (from-to)1147-62
Number of pages16
ISSN1053-2498
DOIs
Publication statusPublished - Dec 2013

ID: 42217956