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Testicular cancer

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  1. Gestational diabetes mellitus

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  2. Invasive candidiasis

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  3. Bipolar disorders

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  4. Antiphospholipid syndrome

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  5. Narcolepsy

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  1. Sexual Function and Quality of Life in a National Cohort of Survivors of Bilateral Testicular Cancer

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  2. Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

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  3. Mortality and admission to intensive care units after febrile neutropenia in patients with cancer

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  4. Prospective molecular and morphological assessment of testicular prepubertal-type teratomas in postpubertal men

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  5. Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study

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  • Liang Cheng
  • Peter Albers
  • Daniel M Berney
  • Darren R Feldman
  • Gedske Daugaard
  • Timothy Gilligan
  • Leendert H J Looijenga
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Testicular cancer is the most common malignancy among men between 14 and 44 years of age, and its incidence has risen over the past two decades in Western countries. Both genetic and environmental factors contribute to the development of testicular cancer, for which cryptorchidism is the most common risk factor. Progress has been made in our understanding of the disease since the initial description of carcinoma in situ of the testis in 1972 (now referred to as germ cell neoplasia in situ), which has led to improved treatment options. The combination of surgery and cisplatin-based chemotherapy has resulted in a cure rate of >90% in patients with testicular cancer, although some patients become refractory to chemotherapy or have a late relapse; an improved understanding of the molecular determinants underlying tumour sensitivity and resistance may lead to the development of novel therapies for these patients. This Primer provides an overview of the biology, epidemiology, diagnosis and current treatment guidelines for testicular cancer, with a focus on germ cell tumours. We also outline areas for future research and what to expect in the next decade for testicular cancer.

Original languageEnglish
JournalNature reviews. Disease primers
Volume4
Issue number1
Pages (from-to)29
ISSN2056-676X
DOIs
Publication statusPublished - 5 Oct 2018

ID: 55865158