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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Terapeutisk cancervaccination mod hæmatologisk cancer

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  1. Integration af specialiseret palliation og onkologi

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  2. Formodet SARS-CoV-2-dødsfald hos en tidligere rask 50-årig mand

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  3. Akut luftvejsobstruktion grundet uerkendt akalasi efter ukompliceret vaginal fødsel

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  4. Dansk Kvalitetsdatabase for Nyfødte (DKN) -resumé af årsrapport 2018. Indikator 9: antibiotikabehandling

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  5. Lokalanæstesitorakoskopi ved udredning af recidiverende pleuraeffusion

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  1. Evidence of immune elimination, immuno-editing and immune escape in patients with hematological cancer

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  2. Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope

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  3. Inflammation induced PD-L1-specific T cells

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  4. MERTK Acts as a Costimulatory Receptor on Human CD8+ T Cells

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Few trials testing the clinical efficacy of therapeutic cancer vaccination have been successful, and therapeutic cancer vaccines are yet to enter the clinic for treatment of haematological cancers. The review summarises the present knowledge of the interplay between cancer and the immune system. These novel insights have uncovered knowledge, which can be used to enhance the effect of therapeutic cancer vaccines in haematology. Immune checkpoint inhibitors, immunomodulating agents, radiotherapy and vaccination against regulatory mechanisms can potentially increase the clinical effect of cancer vaccines for haematological cancer.

Translated title of the contributionTherapeutic cancer vaccination for treatment of haematological cancers
Original languageDanish
JournalUgeskrift for Laeger
Volume181
Issue number20A
ISSN0041-5782
Publication statusPublished - 14 Oct 2019

ID: 58521609