Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Tension-type headache

Research output: Contribution to journalReviewpeer-review

  1. Contact dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Motile ciliopathies

    Research output: Contribution to journalReviewpeer-review

  3. Gestational diabetes mellitus

    Research output: Contribution to journalReviewpeer-review

  4. Testicular cancer

    Research output: Contribution to journalReviewpeer-review

  5. Invasive candidiasis

    Research output: Contribution to journalReviewpeer-review

  1. Prevalence of pre-cluster symptoms in episodic cluster headache: Is it possible to predict an upcoming bout?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hypersensitivity to calcitonin gene-related peptide in chronic migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dependence-like behaviour in patients treated for medication overuse headache: A prospective open-label randomized controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Real-life treatment of cluster headache in a tertiary headache center - results from the Danish Cluster Headache Survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Sait Ashina
  • Dimos D Mitsikostas
  • Mi Ji Lee
  • Nooshin Yamani
  • Shuu-Jiun Wang
  • Roberta Messina
  • Håkan Ashina
  • Dawn C Buse
  • Patricia Pozo-Rosich
  • Rigmor H Jensen
  • Hans-Christoph Diener
  • Richard B Lipton
View graph of relations

Tension-type headache (TTH) is the most prevalent neurological disorder worldwide and is characterized by recurrent headaches of mild to moderate intensity, bilateral location, pressing or tightening quality, and no aggravation by routine physical activity. Diagnosis is based on headache history and the exclusion of alternative diagnoses, with clinical criteria provided by the International Classification of Headache Disorders, third edition. Although the biological underpinnings remain unresolved, it seems likely that peripheral mechanisms are responsible for the genesis of pain in TTH, whereas central sensitization may be involved in transformation from episodic to chronic TTH. Pharmacological therapy is the mainstay of clinical management and can be divided into acute and preventive treatments. Simple analgesics have evidence-based effectiveness and are widely regarded as first-line medications for the acute treatment of TTH. Preventive treatment should be considered in individuals with frequent episodic and chronic TTH, and if simple analgesics are ineffective, poorly tolerated or contraindicated. Recommended preventive treatments include amitriptyline, venlafaxine and mirtazapine, as well as some selected non-pharmacological therapies. Despite the widespread prevalence and associated disability of TTH, little progress has been made since the early 2000s owing to a lack of attention and resource allocation by scientists, funding bodies and the pharmaceutical industry.

Original languageEnglish
JournalNature reviews. Disease primers
Volume7
Issue number1
Pages (from-to)24
ISSN2056-676X
DOIs
Publication statusPublished - 2021

ID: 65609418