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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Temporal trends in the use of antithrombotics at admission

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  1. Minimal important change values for the Oxford Knee Score and the Forgotten Joint Score at 1 year after total knee replacement

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  2. Acetabular cup position and risk of dislocation in primary total hip arthroplasty

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  3. An enhanced treatment program with markedly reduced mortality after a transtibial or higher non-traumatic lower extremity amputation

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  4. Morbidity and mortality after bilateral simultaneous total knee arthroplasty in a fast-track setting

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  5. Good validity and reliability of the forgotten joint score in evaluating the outcome of total knee arthroplasty

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  1. Change in HbA1c concentration as decision parameter for frequency of HbA1c measurement

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  2. Centenarian hip fracture patients: a nationwide population-based cohort study of 507 patients

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  3. Vitamin D levels and Cancer Incidence in 217.244 individuals from Primary Health Care in Denmark

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Background and purpose - Currently, no clear evidence exists on the pattern of use of antithrombotics at admission in hip fracture patients and how this has changed over time. We investigated temporal trends in-and factors associated with-the use of antithrombotics in patients admitted with a fractured hip. Patients and methods - This was a population-based cohort study including all patients aged 18 years or above who were admitted with a hip fracture in Denmark from 1996 to 2012. The Danish national registries were used to collect information on medication use, vital status, and comorbidity. Results - From 1996 to 2012, the proportion of patients using antithrombotics in general increased by a factor of 2.3 from 19% to 43% (p < 0.001). More specifically, the use of anticoagulants increased by a factor of 6.8 and the use of antiplatelets increased by a factor of 2.1. When we adjusted for possible confounders, the use of antithrombotics still increased for every calendar year (relative risk (RR) = 1.03, CI: 1.03-1.04; p < 0.001). Age, sex, and Charlson comorbidity index were all associated with the use of antithrombotics (all p < 0.001). Interpretation - The proportion of hip fracture patients using antithrombotics at admission has increased substantially in Denmark over the last 2 decades. This highlights the need for evidence-based guidelines on how to handle patients using antithrombotics to ensure safe surgery and to avoid surgical delay.

Original languageEnglish
JournalActa Orthopaedica (Online)
Volume87
Issue number4
Pages (from-to)368-73
Number of pages6
ISSN1745-3682
DOIs
Publication statusPublished - Aug 2016

    Research areas

  • Journal Article

ID: 49846241