Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Temporal changes in chromium allergy in Denmark between 2002 and 2017

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Quality of life and disease severity in dermatitis patients with fragrance allergy-A cross-sectional European questionnaire study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Skin tape stripping: Which layers of the epidermis are removed?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Highlights in allergic contact dermatitis 2018/2019

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Necrotic ulcer on the chin of a previously healthy 38-year-old woman

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Quality of life and disease severity in dermatitis patients with fragrance allergy-A cross-sectional European questionnaire study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Would you like to purchase a rodent with dermatophytes?

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: In 2012, Danish authorities submitted a proposal to the European Chemical Agency restricting the content of hexavalent chromium to a maximum of 3 ppm in leather goods. Following its adoption, this proposal was implemented in 2015 as a directive in the EU.

OBJECTIVES: To examine the temporal trend of chromium contact allergy in adult dermatitis patients patch tested between 2002 and 2017, and to determine clinical characteristics and causative exposures in these patients.

METHODS: All adult dermatitis patients patch tested between 2002 and 2017 were included. Patch test data were reviewed retrospectively. Comparisons were performed with the χ 2 test and logistic regression analysis.

RESULTS: A total of 13 379 adults aged 18 to 99 years were patch tested between 2002 and 2017. The overall prevalence of chromium allergy was 2.2%. An overall decreasing trend was found for the prevalence of chromium allergy (Ptrend = 0.00002). Specifically, a significant difference was found for the study periods 2010 to 2013 (Ptrend  = 0.002) and 2014 to 2017 (Ptrend  < 0.0001) as compared with 2002 to 2005. Leather remained the most important single cause of allergic contact dermatitis caused by chromium. The proportion of clinically relevant leather exposures increased from 42.3% during 2002 to 2009 to 54.8% during 2010 to 2017 (P = 0.04).

CONCLUSIONS: The prevalence of chromium allergy is decreasing. The EU Directive restricting the use of hexavalent chromium in leather goods is thought to be playing a central role in this change.

Original languageEnglish
JournalContact Dermatitis
Volume80
Issue number3
Pages (from-to)156-161
Number of pages6
ISSN0105-1873
DOIs
Publication statusPublished - Mar 2019

ID: 56510047