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Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

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Fyhrquist, Frej ; Eriksson, Anders ; Saijonmaa, Outi ; Nordestgaard, Børge G ; Kontula, Kimmo ; de Faire, Ulf ; Ibsen, Hans ; Kjeldsen, Sverre ; Os, Ingrid ; Dahlöf, Björn. / Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy. In: Journal of the Renin-Angiotensin-Aldosterone System. 2013.

Bibtex

@article{684a7470f4074eb1a9e9fbe631c09255,
title = "Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy",
abstract = "INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (",
author = "Frej Fyhrquist and Anders Eriksson and Outi Saijonmaa and Nordestgaard, {B{\o}rge G} and Kimmo Kontula and {de Faire}, Ulf and Hans Ibsen and Sverre Kjeldsen and Ingrid Os and Bj{\"o}rn Dahl{\"o}f",
year = "2013",
doi = "10.1177/1470320312460292",
language = "English",
journal = "JRAAS - Journal of the Renin-Angiotensin-Aldosterone System",
issn = "1470-3203",
publisher = "Sage Science Press (UK)",

}

RIS

TY - JOUR

T1 - Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

AU - Fyhrquist, Frej

AU - Eriksson, Anders

AU - Saijonmaa, Outi

AU - Nordestgaard, Børge G

AU - Kontula, Kimmo

AU - de Faire, Ulf

AU - Ibsen, Hans

AU - Kjeldsen, Sverre

AU - Os, Ingrid

AU - Dahlöf, Björn

PY - 2013

Y1 - 2013

N2 - INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (

AB - INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (

U2 - 10.1177/1470320312460292

DO - 10.1177/1470320312460292

M3 - Journal article

C2 - 23077078

JO - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

JF - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

SN - 1470-3203

ER -

ID: 36785771