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Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

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  • Frej Fyhrquist
  • Anders Eriksson
  • Outi Saijonmaa
  • Børge G Nordestgaard
  • Kimmo Kontula
  • Ulf de Faire
  • Hans Ibsen
  • Sverre Kjeldsen
  • Ingrid Os
  • Björn Dahlöf
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INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (
Original languageEnglish
JournalJournal of the Renin-Angiotensin-Aldosterone System
ISSN1470-3203
DOIs
Publication statusPublished - 2013

ID: 36785771