Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Triglycerides as a shared risk factor between dementia and atherosclerotic cardiovascular disease: a study of 125 727 individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of cardiovascular risk factors and genetics on 10-year absolute risk of dementia: risk charts for targeted prevention

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Elevated plasma YKL-40 and risk of infectious disease: a prospective study of 94665 individuals from the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Low high-density lipoprotein and increased risk of several cancers: 2 population-based cohort studies including 116,728 individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Frej Fyhrquist
  • Anders Eriksson
  • Outi Saijonmaa
  • Børge G Nordestgaard
  • Kimmo Kontula
  • Ulf de Faire
  • Hans Ibsen
  • Sverre Kjeldsen
  • Ingrid Os
  • Björn Dahlöf
View graph of relations
INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I/D genotype with LTL and cardiovascular risk. RESULTS: Mean LTL in DD or ID genotype was shorter (8.15 and 8.14 kb, respectively), than in II genotype (8.27 kb, p=0.0005). This difference was significant in the younger subjects (55-64 years, p=0.02) but not in the older group (65-80 years, p=0.56 ). In DD but not I/D or II genotype, proportion of short telomeres (
Original languageEnglish
JournalJournal of the Renin-Angiotensin-Aldosterone System
ISSN1470-3203
DOIs
Publication statusPublished - 2013

ID: 36785771