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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Targeting the epidermal growth factor receptor in solid tumor malignancies

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  1. Non-pharmacological Effects in Switching Medication: The Nocebo Effect in Switching from Originator to Biosimilar Agent

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  2. Long-acting GLP-1 analogs for the treatment of type 2 diabetes mellitus

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  1. Cell-free DNA in newly diagnosed patients with glioblastoma - a clinical prospective feasibility study

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  2. Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

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  3. Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

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  4. Actively personalized vaccination trial for newly diagnosed glioblastoma

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  5. Extracranial metastases in glioblastoma-Two case stories

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The epidermal growth factor receptor (EGFR) is over-expressed, as well as mutated, in many types of cancers. In particular, the EGFR variant type III mutant (EGFRvIII) has attracted much attention as it is frequently and exclusively found on many tumor cells, and hence both EGFR and EGFRvIII have been proposed as valid targets in many cancer therapy settings. Different strategies have been developed in order to either inhibit EGFR/EGFRvIII activity or to ablate EGFR/EGFRvIII-positive tumor cells. Drugs that inhibit these receptors include monoclonal antibodies (mAbs) that bind to the extracellular part of EGFR, blocking the binding sites for the EGFR ligands, and intracellular tyrosine kinase inhibitors (TKIs) that block the ATP binding site of the tyrosine kinase domain. Besides an EGFRvIII-targeted vaccine, conjugated anti-EGFR mAbs have been used in different settings to deliver lethal agents to the EGFR/EGFRvIII-positive cells; among these are radio-labelled mAbs and immunotoxins. This article reviews the current status and efficacy of EGFR/EGFRvIII-targeted therapies.
Original languageEnglish
JournalBioDrugs
Volume26
Issue number2
Pages (from-to)83-99
Number of pages17
ISSN1173-8804
DOIs
Publication statusPublished - 2012

    Research areas

  • Animals, Antibodies, Monoclonal, Humans, Molecular Targeted Therapy, Neoplasms, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Receptor, Epidermal Growth Factor

ID: 36890041